Drug-like Properties豆瓣评分:0.0 简介:Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become
曾有人在公司内报告过关于Drug-like的故事,现在没有多少印象,多半是因为当时很多知识并不了解,无法真正体会其中含义,要么就是药物的研发的领域实在是过于庞大,一般需要了解一个化合物的诸多特性才可进入临床试验:如结构的特征,包括分子量、氢键结合、极性、构型、亲脂性...
Drug-Like Properties: Concepts, Structure Design and Methods类药性:概念、结构设计与方法 读后感1 第2章 药物性质评估及良好类药性的优势 2.2 候选药物性质优化的主要方面 基于药代和安全性的影响性,按照化合物的性质归纳如下 : 结构性质 -亲脂性(Lipophilicity) -拓扑极性表面积(Topological polar surface area, ...
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The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of ...
I have to admit that this is the most wonderful book focusing on drug-like properties. It is especially valuable for any beginner to start the pharmaceutic exploration. Really excellent. 类似图书 点击查看全场最低价 出版者:Academic Press
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H. Drug-Like Properties: Concepts, Structure Design, and Methods (Elsevier, 2016). This is an excellent book on concepts and methods of drug-like properties. Google Scholar Gobeau, N., Stringer, R., De Buck, S., Tuntland, T. & Faller, B. Evaluation of the GastroPlus Advanced ...
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