Drug-like Properties豆瓣评分:0.0 简介:Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become
Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property ...
I have to admit that this is the most wonderful book focusing on drug-like properties. It is especially valuable for any beginner to start the pharmaceutic exploration. Really excellent. 类似图书 点击查看全场最低价 出版者:Academic Press
曾有人在公司内报告过关于Drug-like的故事,现在没有多少印象,多半是因为当时很多知识并不了解,无法真正体会其中含义,要么就是药物的研发的领域实在是过于庞大,一般需要了解一个化合物的诸多特性才可进入临床试验:如结构的特征,包括分子量、氢键结合、极性、构型、亲脂性...
Drug-like Properties: Concepts, Structure Design and Methods Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: ... DEK Li - ELSEVIER 被引量: 110发表: 2016年 An Improved Small-Molecule Inhibitor ...
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including ...
Drug-like Properties: Concepts, Structure Design and Methods Kerns E, Di L (2008) Drug-like properties: concepts, structure design and methods. from ADME to toxicity optimization. Academic Press, San Diego, pp ... DEK Li - ELSEVIER 被引量: 110发表: 2016年 Getting physical in drug ...
Drug-Like Properties: Concepts, Structure Design and Methods类药性:概念、结构设计与方法 读后感1 第2章 药物性质评估及良好类药性的优 2.2 候选药物性质优化的主要方面 基于药代和安全性的影响性,按照化合物的性质归纳如下 : 结构性质 -亲脂性(Lipophilicity)...
Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property...