Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition,provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility ...
Drug-like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization 1st Edition - July 26, 2010 Authors:Li Di, Edward H Kerns Language: English eBook ISBN:9780080951621 9 7 8 - 0 - 0 8 - 0 9 5 1 6 2 - 1 ...
et al. Improvement of drug-like properties of peptides: the somatostatin paradigm. Expert Opin. Drug Discov. 5, 655–671 (2010). Article CAS PubMed Google Scholar Jevsevar, S., Kunstelj, M. & Porekar, V. G. PEGylation of therapeutic proteins. Biotechnol. J. 5, 113–128 (2010)...
Adj.1.sedative- tending to soothe or tranquilize; "valium has a tranquilizing effect"; "took a hot drink with sedative properties before going to bed" ataractic,ataraxic,tranquilising,tranquilizing,tranquillising,tranquillizing depressant- capable of depressing physiological or psychological activity or...
Took another deep drag of his cigarette, letting the smoke curl up out of his mouth and around his head like ectoplasm —Margaret Millar To smoke a cigar through a mouthpiece is the equivalent of kissing a lady through a respirator —Anon Similes Dictionary, 1st Edition. © 1988 The Gale...
ASI holds 7 key domains: medical status, employment and support, drug and alcohol use, legal status, social and psychiatric status [71, 72], and has sound psychometric properties [73]. In the present IPS-ADAS trial, the ASI interview questions are replied online (RedCap), with support ...
nanoparticles with different chemical compositions due to their distinct dissolution profiles with pH changes. Physical properties like particle interfaces also count for the pH modulation ability. Due to the effective tumour accumulation, calcium nanomaterials elevate Ca2+concentrations in tumour TME and ...
(Miller & Rollnick, 1991), and discussing what goals for change the student would like to select and pursue. Consistent with an MI approach, students are allowed to negotiate goals with the counselor, although drug abstinence is encouraged. Session 2 focuses on the students' progress in ...
•以全面的动物和人体数据为指导,这些数据广泛关注制剂的特性和动物的适宜性,以及(Is guided by a comprehensive set of animal and human data that focus broadly on the properties of the agent and the suitability of the animal, and) •允许在临床使用的...
Fiber, much like calcium, works to bind drugs, resulting in decreased concentrations. For example, patients with diabetes who try to decrease their cholesterol levels by eating oatmeal after taking metformin might be worsening their diabetic control. Metformin blood levels are decreased when taken with...