Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress. Curr. Drug Metab. 15, ... KSPC Bhattacharyya - 《Current Drug Metabolism》 被引量: 0发表: 2014年 Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and ...
3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the inhibitory or inducing effects of drugs on enzyme activity. In vitro data have been utilized to predict clinical outcomes (i.e., ...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
罗沙司他半衰期为12.8 h,每周口服给药2~3次,主要通过细胞色素P450(cytochrome P450,CYP)2C8代谢并通过和葡糖醛酸转移酶结合排泄[13],罗沙司他间歇性给药方式可以长期维持治疗效果,不会导致治疗敏感性降低。此外,药代动力学研究发现,饮食对罗沙司他无显著影响,罗沙司他可空腹服用或与食物同服[14]。由于透析不对...
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation Plant-parasitic nematodes have the potential to destroy crops globally, and limited options for managing nematode infestation are available. Here, the authors report the 1,3,4-oxadiazole thioether scaffold called Cyprocide that sele...
(-rays, X-rays, high energy UV, fast neutron) caused by environmental pollution or clinical treatments and the effects of non-ionizing radiation (low energy UV) on the expression and/or activity of drug metabolism (e.g., cytochrome P450 (CYP), glutathione transferase (GST)), enzymes ...
Myeloperoxidase Cytochrome P450 Drug metabolites Heme H2O2 Free radicals 1. Introduction Drug metabolism is the process by which a xenobiotic substrate is structurally altered in the body, usually via enzyme catalysis. In addition, a xenobiotic is a relatively small non-nutrient chemical that is exogen...
CYP cytochrome P450 GP glycoprotein MI myocardial infarction PCI percutaneous coronary intervention PCR polymerase chain reaction RPA residual platelet aggregation After administration of clopidogrel, high on-treatment platelet reactivity is associated with increased risk of adverse events after percutaneous corona...