Cytochrome P450 in Human Drug Metabolism: How Much is Predictable? In: Waterman, Hildebrand, eds. Assessment of the use of single cytochrome P450 enzymes in drug research. Berlin, Heidelberg, New York:Springer Verlag; 1994, pp. 43-56.Cytochrome P450 in Human Drug Metabolism: How Much is ...
metabole--change DrugMetabolism– CytochromeP450 Substratescanundergoabroadrangeof reactionsduringmetabolism. Thesereactionsinclude,forexample, oxidation,reduction,hydrolysis,hydration, conjugationandcondensation. Drugmetabolismisdividedinto2Phases-- PhaseIwhicharethefunctionalization reactions; AndPhaseII,whicharethe...
Ji L, Faponle AS, Quesne MG et al (2015) Drug metabolism by cytochrome P450 enzymes: what distinguishes the pathways lead- ing to substrate hydroxylation over desaturation? Chem A Eur J 21:9083-9092Ji L, Faponle AS, Quesne MG, et al. Drug metabolism by cytochrome P450 enzymes: what ...
Drug–drug interactions and metabolism in cytochrome P450 2C knockout mice: Application to troleandomycin and midazolamdoi:10.1016/j.bcp.2013.05.015Cyp2c\\{KO\\}mouseDDIMetabolismMidazolamTroleandomycinDrug鈥揹rug interactions (DDIs) may cause serious drug toxicity and delay development of candidate ...
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 2013;138:103-... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0...
Kramer MA, Tracy TS. 2008. Studying cytochrome P450 kinetics in drug metabolism. Expert Opin Drug Metab Toxicol 4(5):591-603.Kramer MA, Tracy TS. Studying cytochrome P450 kinetics in drug metabolism. Expert opinion on drug metabolism & toxicology 2008; 4(5):591-603....
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
Vermeulen N.P. (2003) Prediction of drug metabolism: the case of cytochrome P450 2D6. Curr Top Med Chem;3:1227-1239.P.E. Vermeulen, Prediction of drug metabolism: the case of cytochrome P450 2D6, Curr. Top. Med. Chem. 3 (2003) 1227-1239....
Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to...
The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional monooxygenases critical for the metabolism of numerous endogenous and exogenous compounds. The superfamily is organized into 18 families and 44 subfamilies. CYP nomenclature is based on the identity of amino acids. The mos...