"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation." Pharmacol Ther 138(1): ... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0发...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the inhibitory or inducing effects of drugs on enzyme activity. In vitro data have been utilized to predict clinical outcomes (i.e., ...
The cytochrome P450 (P450) enzymes are the major catalysts involved in the metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug development today, and P450 and the conjugation enzymes can influence these effects. The toxicity of drugs can be considered in ...
Myeloperoxidase Cytochrome P450 Drug metabolites Heme H2O2 Free radicals 1. Introduction Drug metabolism is the process by which a xenobiotic substrate is structurally altered in the body, usually via enzyme catalysis. In addition, a xenobiotic is a relatively small non-nutrient chemical that is exogen...
Drug Metabolism: Cytochrome P450 Reference Module in Biomedical Sciences 2021 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. Looking for a customized option? Contact sales for special pricing for your organizationCont...
Drug Metabolism and Disposition, 2018. 46(6): p. 835-845. 3. T Y., et al., Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19. Journal of clinical pharmacology, 2017. 57(11): p. 1491-1499. 4. CK I., et al., Impact of ...
【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ... 美国库房发货,通常付款后3-5周到货! 作者:Lee, Jae S.出版社:CRC Press出版时间:2003年09月 手机专享价 ¥ 当当价 降价通知 ¥2713 配送至 北京 至 北京市东城区 服务 由“中国进口图书旗舰店”发货,并...
(-rays, X-rays, high energy UV, fast neutron) caused by environmental pollution or clinical treatments and the effects of non-ionizing radiation (low energy UV) on the expression and/or activity of drug metabolism (e.g., cytochrome P450 (CYP), glutathione transferase (GST)), enzymes ...
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these enzymes result in changes in pharmacokinetics (and consequently the pharmacodynamics) of drugs that are metabolized by this set of enzymes. Ap...