Myeloperoxidase Cytochrome P450 Drug metabolites Heme H2O2 Free radicals 1. Introduction Drug metabolism is the process by which a xenobiotic substrate is structurally altered in the body, usually via enzyme catalysis. In addition, a xenobiotic is a relatively small non-nutrient chemical that is exogen...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
Cytochrome P450(CYP) is a family of the body's more powerful detox enzymes that involves in the biotransformation of various endogenous and exogenous compounds including clinical drugs.Genetic and phenotypic polymorphism of CYP results in the individual differences of xenobiotic metabolisms.Nuclear recepto...
【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ... 美国库房发货,通常付款后3-5周到货! 作者:Lee, Jae S.出版社:CRC Press出版时间:2003年09月 手机专享价 ¥ 当当价降价通知 ¥2713 配送至 北京 至北京市东城区...
3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the inhibitory or inducing effects of drugs on enzyme activity. In vitro data have been utilized to predict clinical outcomes (i.e., ...
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these enzymes result in changes in pharmacokinetics (and consequently the pharmacodynamics) of drugs that are metabolized by this set of enzymes. Ap...
The recent identification of drug-metabolizing enzymes cytochrome P450 (CYP) in the human blood-brain barrier (BBB) raises the question of whether these en... X Decleves,A Jacob,S Yousif,... - 《Current Drug Metabolism》 被引量: 87发表: 2011年 Interaction of drug metabolizing cytochrome P45...
metabolizing enzymes such as those of the cytochrome P450 family (CYPs) [10,14] or UDP-glycosyltransferases [15]. Cytochrome P450 enzymes play a pivotal role in catalyzing the oxidative metabolism of xenobiotics, including 70–80% of all those in clinical use [16]. CYPs catalyze various ...
(-rays, X-rays, high energy UV, fast neutron) caused by environmental pollution or clinical treatments and the effects of non-ionizing radiation (low energy UV) on the expression and/or activity of drug metabolism (e.g., cytochrome P450 (CYP), glutathione transferase (GST)), enzymes ...
The current work explored this field with a focus on the AILI-mediated alterations of cytochrome P450–mediated drug metabolism. Various levels of liver injury were induced in mice by treatment with APAP at 0, 200, 400, and 600 mg/kg. Severity of liver damage was determined at 24, 48, ...