Preclinical drug metabolism and pharmacokinetic evaluation of GW844520GW844520, a non-chiral 4(1H)-pyridone derivative, is a potent, selective inhibitor of Plasmodium mitochondrial function blocking the electron transport chain machinery. The site of action of this class of compounds is cytochrome b, ...
DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 2014;42(Database issue):D1091–7. Article CAS PubMed Google Scholar Tatonetti NP, Ye PP, Daneshjou R, Altman RB. Data-driven prediction of drug effects and interactions. Sci Transl Med. 2012;4(125):125ra131. ...
内容提示: Current Drug Metabolism, 2001, 2, 117-137 117 1389-2002/01 $28.00+.00 © 2001 Bentham Science Publishers Ltd.Analysis of Mammalian Cytochrome P450 Structure and Function by Site-Directed MutagenesisT. L. Domanski and J.R. Halpert*Department of Pharmacology and Toxicology, University...
Previously we focused on mapping genomic regions known to contain genes en- coding various enzymes and transporters involved in the metabolism of drugs, and constructed integrated gene maps of 145 target regions containing SNPs and other types of variations (Iida et al. 2001a–d; 2002a–e; ...
Metabolism: RD-V (Rabeprazole) is extensively metabolized. A significant portion of RD-V (Rabeprazole) is metabolized via systemic nonenzymatic reduction to a thioether compound. RD-V (Rabeprazole) is also metabolized to sulphone and desmethyl compounds via cytochrome P450 in the liver. The thioether...
binding energy of antiviral BIA dimmers. The X-axis is the original value times minus one. Source data are provided as a Source Data file. Full size image A systematic survey of intermediate compounds in cepharanthine (1) biosynthesis pathway may reveal the crucial reactions and enzymes for ...
Cytochrome P450 (CYP) Enzyme Inducers: Phenobarbital, which induces hepatic metabolism, decreased the area under the plasma concentration curve (AUC) of Rid-AR (Montelukast Sodium) approximately 40% following a single 10 mg dose of Rid-AR (Montelukast Sodium). No dosage adjustment for Rid-AR (...
Given the extensive cytochrome P450 (CYP) metabolism of ATV [42], [43], [44], we also fit Michaelis-Menton kinetic parameters—Vmax (the maximum rate achieved by the enzymatic system, at saturating substrate concentration) and km (the substrate concentration at which the enzymatic reaction rate...
(PPREs) of target genes involved in insulin signaling, lipid and glucose metabolism, immune response, as well as cell cycle and differentiation46,47. Several activators with different selectivity for the respective PPAR subtypes have reached advanced clinical trials or were introduced to the market....
Schoretsanitis G, Haen E, Stegmann B, Hiemke C, Grunder G, Paulzen M (2017) Effect of smoking on risperidone pharmacokinetics - a multifactorial approach to better predict the influence on drug metabolism. Schizophr Res 185:51–57 Funding ...