Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other substances of abuse, such as tobacco. Cytochrome P450 2E1 (CYP2E1), which is induced by alcohol, is mainly involved in alcohol metabolism in the...
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Acetaldehyde can form adducts which can interfere with cellular fun...
it takes part in the metabolism of many drugs, steroids and carcinogens [1]. The most intensively studied route of drug metabolism is the P450-catalysed mixed-function oxidation reaction which conforms to the following
BACKGROUND/AIMS: Alcohol dehydrogenase, cytochrome P4502E1 (CYP2E1), and aldehyde dehydrogenase are known to play an important role in alcohol metabolism in the liver. Although the ethanol oxidation pathways are mainly localized in hepatocytes, we examine whether human hepatic stellate cells might ...
P450 to O2, yielding O2−and other ROS (Hanukoglu, 2006). In the ovary, for instance, antioxidant enzyme activities of SOD, catalase and GSH-Px parallel steroidogenesis (Sugino et al., 2000), since overproduced ROS associated with oestrogen metabolism is closely associated with genotoxicity ...
Breast cancer risk may be determined by various genetic, metabolic, and lifestyle factors that alter sex hormone metabolism. Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine. In
1 To a lesser extent, they are also involved in xenobiotic metabolism in other organs, such as intestine, brain, and kidney. CYP2E1 is known to metabolize ethanol in the liver, especially in chronic alcohol users;2 however, the persistent use of alcohol and resulting alcohol metabolism is ...
Safety Issues Concerning the Use of Disulfiram in Treating Alcohol Dependence Of note, there are drug interactions with compounds that utilise the cytochrome P450 enzyme system.Disulfiram can be viewed as a drug with a moderate ... J Chick - 《Drug Safety》 被引量: 269发表: 1999年 ...
In substrate-bound StvP2 structure, a highly conserved “acid-alcohol” pair (Asp242-Ser243) (Fig.4b) is positioned at a kink formed in the middle of the I helix (Asp227-Leu256), which is commonly a Glu/Asp-Thr pair (Ser could be considered as the one less carbon analog of Thr)...
14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] mutilin (DPTM) is a promising drug candidate with excellent antibacterial activity against Gram-positive bacteria. The present study was designed to characterize its Cytochrome P450 (CYP) enzymes inhibition a