Guengerich FP, Gillam EMJ, Martin MV, Baba T, Kim BR, Shimada T, Raney KD, and Yun CH (1994) The importance of cytochrome P450 3A enzymes in drug metabolism, in Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research (Waterman MR and Hildebrand M eds) pp 161-186, ...
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 2013;138:103-... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0...
Thus, inhibition of CYPs may lead to the toxicity or lack of efficacy of a drug.例题演练(二)参考答案:细胞色素P450 (CYP)酶抑制是基于代谢的药物-药物相互作用的主要机制,通常涉及一种药与另一种药物竞争相同的酶结合位点。例如,去甲丙咪嗪由CYP2D6代谢,它的代谢可受到与同一同工酶结合的氟西汀的强烈...
Cytochrome P450 In subject area: Neuroscience Cytochrome P450 is a major drug-metabolizing enzyme that, when overexpressed near a brain tumor, sensitizes cancer cells to certain chemotherapy drugs by converting them into cytotoxic compounds, leading to cell death. AI generated definition based on: Hand...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to...
About 40% of cytochrome P450 dependent drug metabolism is catalysed by polymorphic enzymes and such drug P450 interactions are frequently seen in adverse drug reaction reports. In this contribution an update of hu- man cytochrome P450 enzymology and pharmacogenetics is given with particular emphasis on...
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem 15: 5047-5060.Bruno, RD, Njar, VC (2007) Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem 15(15): 5047-5060....
P450 enzyme classification In man there are around 30 CYP enzymes which are responsible for drug metabolism and these belong to families 1–4. It has been estimated, however, that 90% of drug oxidation can be attributed to six main enzymes: CYP 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 [...
We summarize the role of cytochrome P450 enzymes in the resistance and bioactivation of several antitumor agents, their induction and repression mechanisms and the effect of genetic polymorphisms on variability of drug metabolization. The understanding of genetic variability will help to develop new ...