Bibi Z. Role of cytochrome P450 in drug interactions. Nutrition & Metabolism. 2008;5(27): doi: 10.1186/1743-7075-5-27.Bibi Z, Role of Cytochrome P450 in drug interactions, Nutrition & Metabolism, 2008;5:27 doi:10.1186/1743-7075-5-27...
it takes part in the metabolism of many drugs, steroids and carcinogens [1]. The most intensively studied route of drug metabolism is the P450-catalysed mixed-function oxidation reaction which conforms to the following
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to metabolize more than 100 drugs. CYP2C8 substrate drugs include amodiaquine, cerivastatin, dasabuvir, enzalutamide, imatinib...
We summarize the role of cytochrome P450 enzymes in the resistance and bioactivation of several antitumor agents, their induction and repression mechanisms and the effect of genetic polymorphisms on variability of drug metabolization. The understanding of genetic variability will help to develop new ...
The role of cytochrome P450 pharmacogenomics in chronic noncancer pain patients. Tverdohleb T,Dinc B,Knezevic I,et al. Expert Opin Drug Metab Toxicol . 2016Tverdohleb, T.; Dinc, B.; Knezevic, I.; Candido, K.D.; Knezevic, N.N. The role of cytochrome P450 pharmacogenomics in chronic ...
Numerous sources of human heterogeneity affect biotransformation of compounds. Cytochrome P450, the primary oxidative pathway of drug metabolism, is the dominant phase I oxidative system metabolizing, to some degree, most of the drugs used clinically in humans. The P450 pathway is a major site of ...
FMO, like cytochrome P4... SK Krueger,DE Williams - 《Pharmacology Therapeutics》 被引量: 468发表: 2005年 The role of individual human cytochromes P450 in drug metabolism and clinical response. Recent advances in the study of human cytochromes P450 by protein purification, molecular cloning ...
The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes 来自 Wiley 喜欢 0 阅读量: 25 作者: AG Renwick 摘要: The non-sedating antihistamines show a diversity of fates in the body and the parent drugs and metabolites may differ in their biological properties. ...
Phase I cytochrome P450 (CYP450) enzymes can lead to altered drug metabolism and formation of toxic metabolites, whilst Phase II enzymes are also associated with DILI. The emerging role of hepatic transporters in regulating the movement of endogenous and exogenous chemicals (e.g., bile acids and...
Hyperoxia contributes to lung injury in experimental animals and diseases such as acute respiratory distress syndrome in humans. Cytochrome P450 (CYP)1A enzymes are protective against hyperoxic lung injury (HLI). The molecular pathways and differences in