Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation." Pharmacol Ther 138(1): ... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0发...
Cytochrome monooxygenases P450 enzymes (CYPs) are terminal oxidases, belonging to the multi-gene family of heme-thiolate enzymes and located in multiple sites of ER, cytosol and mitochondria. CYPs act as catalysts in drugs metabolism.This review highlights the mitochondrial and microsomal CYPs metaboli...
Characterization of human liver cytochrome P450 enzymes involved in the metabolism of rutaecarpine 热度: Importance of Amino Acid Residue 474 for Substrate Specificity of Canine and Human Cytochrome P450 3A Enzymes 热度: 细胞色素P450 2C9新等位基因的发现及其对药物代谢的影响 ...
罗沙司他半衰期为12.8 h,每周口服给药2~3次,主要通过细胞色素P450(cytochrome P450,CYP)2C8代谢并通过和葡糖醛酸转移酶结合排泄[13],罗沙司他间歇性给药方式可以长期维持治疗效果,不会导致治疗敏感性降低。此外,药代动力学研究发现,饮食对罗沙司他无显著影响,罗沙司他可空腹服用或与食物同服[14]。由于透析不对...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the inhibitory or inducing effects of drugs on enzyme activity. In vitro data have been utilized to predict clinical outcomes (i.e., ...
Myeloperoxidase Cytochrome P450 Drug metabolites Heme H2O2 Free radicals 1. Introduction Drug metabolism is the process by which a xenobiotic substrate is structurally altered in the body, usually via enzyme catalysis. In addition, a xenobiotic is a relatively small non-nutrient chemical that is exogen...
Cyprocide selectively kills nematodes via cytochrome P450 bioactivation Plant-parasitic nematodes have the potential to destroy crops globally, and limited options for managing nematode infestation are available. Here, the authors report the 1,3,4-oxadiazole thioether scaffold called Cyprocide that sele...
Cytochrome P450 in the Brain ; A Review After many frustrating decades of unsuccessful attempts to characterize the isoforms of P450 in the brain, several scientific breakthroughs in the 80s and ... Hedlund,Gustafsson,Warner - 《Current Drug Metabolism》 被引量: 188发表: 2001年 Constitutive expres...