目的:药物代谢是药物在体内消除的主要决定因素,代谢的主要部位是肝脏,最主要代谢酶为细胞色素P450(cytochromeP450,CYP450),由于地域、种族、遗传、个体差异使该酶呈现出基因多态性,导致对药物代谢存在明显的个体差异,从而对不同个体的药物疗效和不良反应产生重要的影响。 3. And furtherly study the metabolism of Ginse...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
当当中国进口图书旗舰店在线销售正版《【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ...》。最新《【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ...》简介、书评、试读、价格、图
‘thirdgeneration’antidepressants,andatypicalantipsychotics,i.e.clozapine,risperidone,olanzapine,quetiapine,ziprasidoneandamisulpride.TheseagentsareextensivelymetabolizedintheliverbycytochromeP450(CYP)enzymesandarethereforesusceptibletometabolicallybaseddruginteractionswithotherpsychotropicmedicationsorwithcompoundsusedforthe...
Cytochrome P450(CYP) is the principal oxidation enzymes responsible for the metabolism of manyanti-epileptic drugs. 细胞色素P450(CYP)氧化酶是许多抗癫 药物(AEDs)的代谢酶,许多研究证实CYP基因存在遗传多态性并存在种族差异,其多态性可影响抗癫 药物的血药浓度。
Current Drug MetabolismDanielson PB. (2002). The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab 3: 561-97.Danielson, P.B. The Cytochrome P450- Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans. Curr. Drug. Metalab. 2002, 3,...
The cytochrome P450 (P450) enzymes are the major catalysts involved in the metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug development today, and P450 and the conjugation enzymes can influence these effects. The toxicity of drugs can be considered in ...
Bothdrug metabolic enzymeand transport protein are the key factors that govern the transport and metabolism of drugs in the human body. 药物代谢酶和转运蛋白是决定药物体内过程的关键因素,底物对它们的抑制或诱导作用是药物联合应用时产生药动学相互作用的主要机制。