Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
metabole--change DrugMetabolism– CytochromeP450 Substratescanundergoabroadrangeof reactionsduringmetabolism. Thesereactionsinclude,forexample, oxidation,reduction,hydrolysis,hydration, conjugationandcondensation. Drugmetabolismisdividedinto2Phases-- PhaseIwhicharethefunctionalization reactions; AndPhaseII,whicharethe...
Cytochrome \{P450\} enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation 来自 Elsevier 喜欢 0 阅读量: 99 作者:Ulrich,M.,Zanger,and,Matthias,Schwab 摘要: Cytochromes \\{P450\\} (CYP) are a major source of variability in drug ...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
Flockhart DA:Drug interactions and the cytochrome P450: system. The role of cytochrome P4502C19.Clin Pharmacokinet1995,29 Suppl 1:45-52. ArticleCASGoogle Scholar Von Moltke LL, Greenblatt DJ, Schmider J, Harmatz JS, Shader RI:Metabolism of drugs by cytochrome P450, 3A isoforms. Implications ...
Abstract The cytochrome P450s are responsible for about75% of phase I dependent drug metabolism and for themetabolism of a huge amount of die..
The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional monooxygenases critical for the metabolism of numerous endogenous and exogenous compounds. The superfamily is organized into 18 families and 44 subfamilies. CYP nomenclature is based on the identity of amino acids. The mos...
Recently, several mutants of cytochrome P450 BM3 (CYP102A1) with high activity toward drugs have been obtained by a combination of site-directed and random mutagenesis. In the present study, the applicability of these mutants as biocatalysts in the production of reactive metabolites from the drugs...
Recombinant cytochrome P450 (P450) phenotyping, different approaches for estimating fraction metabolized (fm), and multiple measures of in vivo inhibitor exposure were tested for their ability to predict drug interaction magnitude in dog... BM Mills,MJ Zaya,RR Walters,... - 《Drug Metabolism & Di...
- 《Drug Metabolism & Disposition the Biological Fate of Chemicals》 被引量: 93发表: 2001年 The potential pharmacological and toxicological impact of P450 screening. Drug InteractionsMicrosomes, LiverCytochrome P450 (CYP) proteins catalyze the majority of drug biotransformations and play a pivotal role...