Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
Cytochrome \{P450\} enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation 来自 Elsevier 喜欢 0 阅读量: 99 作者:Ulrich,M.,Zanger,and,Matthias,Schwab 摘要: Cytochromes \\{P450\\} (CYP) are a major source of variability in drug ...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
Metabolism of drugs takes place through two different consecutive phases named “phase I” and “phase II”. Cytochrome P450s (CYPs) are major Phase I enzymes while glutathione-S-transferases (GSTs), and UDP-glucuronosyltransferases (UGTs), are the major enzymes belonging to Phase II enzymes...
Human drug metabolising cytochrome P450 enzymes:properties and polymorphisms Received:7 July 2003/Accepted:5 September 2003/Published online:22 October 2003©Springer-Verlag 2003 Abstract The cytochrome P450s are responsible for about 75%of phase I dependent drug metabolism and for the metabolism of ...
Prediction of drug-drug interactions due to cytochrome P450 isoform 3A4 (CYP3A4) overexpression is important because this CYP isoform is involved in the me... H Vermet,N Raoust,R Ngo,... - 《Drug Metabolism & Disposition》 被引量: 11发表: 2015年 Non-Dissociative Sequential Metabolism of ...
Activation of the Acute Inflammatory Response Alters Cytochrome P450 Expression and Eicosanoid Metabolism. Drug Metab. Dispos. 2011, 39, 22–29. [Google Scholar] [CrossRef] [Green Version] Sehgal, N.; Agarwal, V.; Valli, R.K.; Joshi, S.D.; Antonovic, L.; Strobel, H.W.; Ravindran...
[11].Jarrar, Y.B., et al., Identification of cytochrome P450s involved in the metabolism of arachidonic acid in human platelets. Prostaglandins Leukot Essent Fatty Acids, 2013. 89(4): p. 227-34. [12]. Geraldo, R.B., et al., Platelets: still a therapeutical target for haemostatic di...
R Hyland,BC Jones,DA Smith - 《Drug Metabolism & Disposition》 被引量: 743发表: 2003年 Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important cli...
Cytochrome P450 enzymes are found in all life forms. P450s play an important role in drug metabolism, and have potential uses as biocatalysts. Human P450s are membrane-bound proteins. However, the interactions between P450s and their membrane environment are not well-understood. To date, all P4...