目的:药物代谢是药物在体内消除的主要决定因素,代谢的主要部位是肝脏,最主要代谢酶为细胞色素P450(cytochromeP450,CYP450),由于地域、种族、遗传、个体差异使该酶呈现出基因多态性,导致对药物代谢存在明显的个体差异,从而对不同个体的药物疗效和不良反应产生重要的影响。 3. And furtherly study the metabolism of Ginse...
Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other P45...
Metabolism •Sumofprocessesbywhichparticular substancesarehandledbythebody. •FromtheGreek,metabole--change DrugMetabolism– CytochromeP450 Substratescanundergoabroadrangeof reactionsduringmetabolism. Thesereactionsinclude,forexample, oxidation,reduction,hydrolysis,hydration, ...
3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the inhibitory or inducing effects of drugs on enzyme activity. In vitro data have been utilized to predict clinical outcomes (i.e., ...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
当当中国进口图书旗舰店在线销售正版《【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ...》。最新《【预订】Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery ...》简介、书评、试读、价格、图
The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional monooxygenases critical for the metabolism of numerous endogenous and exogenous compounds. The superfamily is organized into 18 families and 44 subfamilies. CYP nomenclature is based on the identity of amino acids. The mos...
Cytochrome P450(CYP) is the principal oxidation enzymes responsible for the metabolism of manyanti-epileptic drugs. 细胞色素P450(CYP)氧化酶是许多抗癫 药物(AEDs)的代谢酶,许多研究证实CYP基因存在遗传多态性并存在种族差异,其多态性可影响抗癫 药物的血药浓度。
Danielson PB.The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Current Drug Metabolism . 2002DANIELSON P B. The cytochrome P450 superfamily : biochemistry, evolution and drug metabolism in humans[J].Current Drug Metabolism,2002,37 (3) :561 - 597....