Cytochrome P450 in Human Drug Metabolism: How Much is Predictable? In: Waterman, Hildebrand, eds. Assessment of the use of single cytochrome P450 enzymes in drug research. Berlin, Heidelberg, New York:Springer Verlag; 1994, pp. 43-56.Cytochrome P450 in Human Drug Metabolism: How Much is ...
, The Ubiquitous Roles of Cytochrome P450 Proteins , Vol. 3, Wiley, Chichester, 2007, pp. 561–589.Astrid S, Helmut S, Roland S (2007) Drug metabolism as catalyzed by human cytochrome P450 systems. In: Metal ions in life sci- ence. Volume 3: the ubiquitous roles of cytochrome P450 ...
Chapter Drug Metabolism Pharmacology Book2009, Pharmacology Kenneth Bachmann Explore book 8.2.3.2 Cytochromes P450 The most widely studied gene family of mixed-function oxidases and the one that participates more than any other in the oxidation of drugs is the cytochrome P450 family. The gene product...
Guengerich FP. Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidations and related reactions.Arch Biochem Biophys. 2003;409:59–71. ArticlePubMedGoogle Scholar Josephy PD, Guengerich FP, Miners JO. Phase 1 and phase 2 drug metabolism: terminology that we should phase...
"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation." Pharmacol Ther 138(1): ... UM Zanger,M Schwab - 《Pharmacology & Therapeutics the Journal of the International Encyclopedia of Pharmacology & Therapeutics》 被引量: 0发...
Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress C. (2014). Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress. Curr. Drug Metab. 15, ... KSPC Bhattacharyya - 《Cur...
The current work explored this field with a focus on the AILI-mediated alterations of cytochrome P450–mediated drug metabolism. Various levels of liver injury were induced in mice by treatment with APAP at 0, 200, 400, and 600 mg/kg. Severity of liver damage was determined at 24, 48, ...
Vermeulen N.P. (2003) Prediction of drug metabolism: the case of cytochrome P450 2D6. Curr Top Med Chem;3:1227-1239.P.E. Vermeulen, Prediction of drug metabolism: the case of cytochrome P450 2D6, Curr. Top. Med. Chem. 3 (2003) 1227-1239....
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...