DNA-binding one zinc-finger (Dof) proteins constitute a family of transcription factors with a highly conserved Dof domain that contains a C2C2 zinc-finger motif. Although several studies have demonstrated that Dof proteins are involved in multiple plant processes, including development and stress ...
Dof(DNAbindingwithonefinger)是植物所特有的一类转录因子,它含有一个独特的富含Cys残基的单锌指保守结构域,命名为Dof结构域。目前,在多种单子叶植物和双子叶植物中都发现了Dof蛋白,它们在高等植物基因表达调控中起作用。水稻的Dof转录因子家族包括30个Dof基因,记为OsDof-1至OsDof-30,分为a、b、c、d4个亚家族...
The DNA binding domain, and discussions of it, are dominated by two “zinc fingers,” each of which contains one zinc atom coordinated by four cysteines (Luisi et al., 1991). The base of each finger (Fig. 2) is sometimes called the “knuckle.” This domain has also been the most ex...
The zinc finger, one of the major structural motifs used for sequence specific DNA binding, has been identified in many regulatory proteins. By analogy, involvement in nucleic acid recognition has been implied for proteins that contain two cysteines and two histidines, spaced in accordance with the...
DNA binding with one finger (Dof) transcription factors play important roles in plant growth and abiotic stress responses. Although genome-wide identification and analysis of the DOF transcription factor family has been reported in other species, no rele
These, together with S66, Q64, and the main chain carbonyl of R63 and T65 at the apical loop (between β2 and α3) of the zinc-finger, form all the base-specific interactions. In one half of the palindrome, N67 of BED1 (shown in yellow, Fig. 2d and Supplementary Fig. 2a with...
Glucocorticoid receptor (GR) binds as a dimer to DNA, with the canonical binding sequence featuring two half-sites, each bound by one monomer, separated by... LC Watson,KM Kuchenbecker,BJ Schiller,... - 《Nature Structural & Molecular Biology》 被引量: 404发表: 2013年 Functional dissection...
RFLAT-1 contains two potent, independent nuclear localization signals; one is immediately upstream of the zinc finger DNA-binding domain, and the other is within the zinc fingers. Using mutational analysis, we also determined that the critical binding sequence of RFLAT-1 is CTCCC. The intact ...
Figure 2. Organization of the two zinc-finger structures found in the DNA-binding domain of the VDR as well as all members of the steroid receptor gene family. C, cysteine residue; Zn, zinc atom. View chapterExplore book Protein-DNA Interactions Preeti Pandey, ... Shandar Ahmad, in Encycl...
This short N-terminal sequence is essential for DNA binding and we suggest it is involved in maintaining the three-dimensional structure of the first finger domain, as has been seen in the nuclear magnetic resonance structure of one of the zinc-finger domains of the yeast transcription factor ...