DNA bindingprotein-protein interactionsThe zinc finger domain is a very ubiquitous structural element whose hallmark is the coordination of a zinc atom by several amino acid residues (cysteines and histidines, and occasionally aspartate and glutamate). These structural elements are associated with ...
Zinc Finger Domaindoi:10.1007/3-540-29623-9_9175The zinc finger domain is a DNA-, RNA-or protein-binding protein motif which creates a finger-like loop. The classical C2H2 Zinc finger binds to zinc via two cysteine(C) residues located one in each......
proteinprotein interactionssolution structurezinc fingerZinc fingers (ZnFs) are generally regarded as DNA-binding motifs. However, a number of recent reports ... K Kowalski,R Czolij,GF King,... - 《Journal of Biomolecular Nmr》 被引量: 99发表: 1999年 Zinc-binding and protein-protein interacti...
The transposase typically assembles into a multimer that recognizes and brings together the TIRs by relying on site-specific DNA-binding domain(s) such as helix-turn-helix or zinc-finger domains, which can be either upstream or downstream of the catalytic domain6. After the formation of the ...
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuc
In the present study, we show that the Dof domain in AOBP truly functions as a zinc finger DNA-binding domain and that the C-terminal region of the Dof domain is also involved in DNA binding. Furthermore, we suggest that the Cys residue uniquely conserved in the putative loop of the Do...
C3H zinc finger factors have four groups: ZC3H8-, ZGPAT-, RC3H, and CNOT4-related factors. 6) C2CH THAP-type zinc finger factors, which bind with preference to a sequence 5’-TTGCCCGTACT-3’, with similarity to the DNA-binding domain of drosophila P-element transposase [29]. Helix...
Zinc finger domain锌指结构域,指反式作用因子中需要有锌离子参与下才具有DNA结合活性的蛋白质亚基
锌指核酸酶(zincfinger nucleases,ZFNs)是科学家为特异性切割DNA构建的工具,由一个DNA识别域和一个DNA剪切域构成.DNA识别域含一到三个锌指蛋白,每个锌指蛋白可以结合一个DNA上的碱基三联体,如GAC,ATA等,几个锌指蛋白串联,可以实现对特异DNA序列的识别;两个DNA剪切域临近时可以产生核酸内切酶活性,将接触的DNA切割开...
Its primary structure suggests that this DNA binding domain may contain a zinc-finger motif. To gain a more detailed insight into this zinc-finger motif, we have measured the 113Cd-NMR spectra of the DNA binding domains derived from the wild-type and mutant XPA proteins. RESULTS: 113Cd-...