A great number of C 2 H 2 zinc finger proteins selectively bind to specific DNA sequences and play a critical role in controlling transcription of genes. The specific binding is achieved by zinc finger domains with 尾尾伪 structure that is formed by tetrahedral binding of Zn 2+ ion to the...
the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci... M Renda,I Baglivo,B Burgess-Beusse,... - 《Journal of Biological Chemistry》 被引量: 274发表: 2007年 The solution structure of the...
Zinc‐finger Geneszinc‐fingerDNA‐binding proteinprotein–protein interactionscysteinehistidineZinc-fingers (ZnFs) are small protein domains stabilized by one or more zinc ions. ZnF proteins are abundant in higher eukaryotes, and many contain multiple ZnF domains. Initially thought to be peculiar to ...
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuc
Zinc finger GATA-like protein1 (ZGLP1, also known as GLP1) is a nuclear protein containing two zinc fingers, one of which is highly homologous to the conserved GATA zinc finger DNA-binding motif. From: Knobil and Neill's Physiology of Reproduction (Fourth Edition), 2015 ...
The zinc finger, one of the major structural motifs used for sequence specific DNA binding, has been identified in many regulatory proteins. By analogy, involvement in nucleic acid recognition has been implied for proteins that contain two cysteines and two histidines, spaced in accordance with the...
By applying the logic of conditional enzymes, we have developed a zinc-finger-dependent recombinase system, the editing activity of which is induced by zinc finger DNA binding. The system combines the precision of recombinases with the DNA target site programmability of zinc finger domains.Nature ...
Guarente. 1989. Mutations that alter transcrip- tional activation but not DNA binding in HAP1. Nature 342: 200-203.Kim, K. S., and L. Guarente, 1989 Mutations that alter transcrip- tional activation but not DNA binding in the zinc finger of yeast activator HAPI. Nature 342: 200-203....
百度试题 题目zincfinger:---___,常出现在DNA结合蛋白中的结构基元,就是有一个含有大约30个氨基酸的环与环上的4个Cys或2个Cys与2个His配位的Zn构成,形成的结构像手指状。相关知识点: 试题来源: 解析 锌指结构 反馈 收藏
This platform includes two zinc-finger DNA binding motifs, that bind predetermined DNA sequences, fused to the catalytic domain of the endonuclease FokI, ... A Mariano 被引量: 0发表: 2013年 加载更多来源期刊 Journal of Inorganic Biochemistry 1993/07/01 ...