Base sequence discrimination by zinc-finger DNA-binding domains. Nature 349:175–178 - Nardelli, Gibson, et al. - 1991 () Citation Context ...nt domain (18) capable of specifically interacting with DNA. Atomic resolution of DNA-zinc finger complexes (25) and comparison of the DNA ...
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuc
Zinc Finger Domaindoi:10.1007/3-540-29623-9_9175The zinc finger domain is a DNA-, RNA-or protein-binding protein motif which creates a finger-like loop. The classical C2H2 Zinc finger binds to zinc via two cysteine(C) residues located one in each......
the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci... M Renda,I Baglivo,B Burgess-Beusse,... - 《Journal of Biological Chemistry》 被引量: 274发表: 2007年 The solution structure of the...
Thus, we investigated whether the Dof domain in AOBP functions as a zinc finger DNA-binding domain. Namely, the importance of each amino acid was assessed by amino acid substitution with site-directed mutagenesis. First, the Cys42 and Cys70 residues of the Dof domain in AOBP, which may ...
Zinc finger GATA-like protein1 (ZGLP1, also known as GLP1) is a nuclear protein containing two zinc fingers, one of which is highly homologous to the conserved GATA zinc finger DNA-binding motif. From: Knobil and Neill's Physiology of Reproduction (Fourth Edition), 2015 ...
The zinc finger of Spt10p is homologous to that of foamy virus integrase, perhaps suggesting that this integrase is also a sequence-specific DNA-binding protein. 展开 关键词: DNAbinding Activator Includes Homologous Integrase DOI: 10.1074/jbc.M511416200 被引量: 46 ...
Nardelli et al., “Zinc finger-DNA recognition: analysis of base specificity by site-directed mutagenesis,” Nuc. Acids Res., 20(16):4137-4144 (1992... Nardelli,Gibson,Charnay - 《Nucleic Acids Research》 被引量: 136发表: 1992年 Development of Zinc Finger Domains for Recognition of the ...
DNA-bind-ing proteinDof/MOA domainPumpkin (Cucurbita sp.)Zinc fingerA unique A/T-rich sequence (5'-AAAAAGTAAAAA-GTAAAAAAGTAAAAAG-3'), referred to as the AGTA repeat, is found in the silencer region of the pumpkin ascorbate oxidase gene. A cDNA for protein (AOBP) that binds to the ...
This platform includes two zinc-finger DNA binding motifs, that bind predetermined DNA sequences, fused to the catalytic domain of the endonuclease FokI, ... A Mariano 被引量: 0发表: 2013年 加载更多来源期刊 Journal of Inorganic Biochemistry 1993/07/01 ...