ZINC FINGER BINDING DOMAIN FOR CNNPROBLEM TO BE SOLVED: To provide polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences represented by formula CNN.BARBAS CARLOS F IIIカルロスエフバルバスザサード...
Zinc Finger Domaindoi:10.1007/3-540-29623-9_9175The zinc finger domain is a DNA-, RNA-or protein-binding protein motif which creates a finger-like loop. The classical C2H2 Zinc finger binds to zinc via two cysteine(C) residues located one in each......
NEMO (NF-κB essential modulator) is a regulatory protein essential to the canonical NF-κB signaling pathway, notably involved in immune and inflammatory responses, apoptosis, and oncogenesis. Here, we report that the zinc finger (ZF) motif, located in the regulatory C-terminal half of NEMO,...
The N-terminal domain of Hermes folds in a CCHC zinc-finger BED motif that specifically interacts with a subterminal repeat Crystals were obtained of the 2:1 BED/LE11-27 complex that were ultimately optimized to diffract to 2.5 Å, and the structure was solved by zinc multiwavelength anom...
1E). Relative to the single zinc fingers, Ran bound to the 4ZnF fragment with a higher stoichiometry, consistent with this region containing multiple zinc finger binding sites. We therefore conclude that: 1) all four Nup153 ZnFs can bind RanGDP; 2) individual ZnF motifs can function as ...
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuc
Providing a polypeptide comprising a zinc finger-nucleotide binding region that binds to a nucleotide sequence shown expressions CNN. Also provided are methods of polypeptides, such compositions and polynucleotides encoding a plurality of polypeptides, such polypeptides and to modulate gene expression using...
ZINC FINGER BINDING DOMAIN FOR GNNPROBLEM TO BE SOLVED: To provide a zinc finger-nucleotide binding polypeptide having binding specificity for target nucleotides. SOLUTION: The zinc finger-nucleotide polypeptide having binding specificity for the target nucleotides containing one or a plurality of GNN ...
PROBLEM TO BE SOLVED: To provide a new polypeptide containing zinc finger domains of a Cys-His family and specifically binding to a target nucleotide of formula: 5'-(ANN)-3'.BARBAS CARLOS FカルロスエフバルバスDREIER BIRGITビルギットドライヤー...
Zinc finger 2 to 12 or which bind to the nucleotide sequence of (ANN) 2-12 formula - a polypeptide comprising the nucleotide binding region is provided. In addition, methods of modulating gene expression by polynucleotide and the polypeptide and polynucleotide encoding the polypeptide are also ...