The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
大多数DNA修复因子在衰老细胞中有所下调,导致修复活性降低,尤其是同源修复途径活性的降低。这表明,清除和降解失败的、潜在不稳定的修复中间产物(如CCF),可能是一种保护基因组完整性或抑制过度DNA损伤反应(DNA damage response, DDR)信号的机制。 表1 细胞质DNA的分子标记物 CCF 与疾病治疗 除了上述CCF和SASP的功能...
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
(2) Teo MY, Seier K, Ostrovnaya I, et al. Alterations in DNA damage response and repair genes as potential marker of clinical benefit from PD-1/PD-L1 blockade in advanced urothelial cancers[J]. Clin Oncol 2018;36:1685-94. (3) Dongfeng Tan, Henry T. Lynch. Principles of Molecular...
DNA damage response (DDR) signatures could emerge early and are enhanced in BM tissues but are eliminated eventually in matched primary CRC tissues. BM-specific mutations in DDR genes and elevated microsatellite instability (MSI) levels support the importance of DDR in the brain metastasis of ...
TheDNA damage response(DDR) involves the activation of numerous cellular activities that repair DNA lesions and maintain genomic integrity, and is critical in preventing tumorigenesis. Inherited or acquired mutations in specific genes involved in the DNA damage response, for example the breast cancer su...
The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single...
In response to DNA breaks, cells initiate a series of signaling pathways, namely DNA damage response (DDR) signaling, mediated by members of the phosphatidylinositol 3-kinase (PI3K)-like kinase (PIKK) family, ATM, ATR and DNA-PK (DNA-dependent kinase). ATM plays a critical role in DNA da...
The proteins encoded by 35 of these genes are involved in DNA repair and in some cases also in other aspects of the DNA damage response such as cell cycle arrest and apoptosis. The polymerase coded for by the 36th gene, XPV (POLH), is involved in bypass (rather than repair) of DNA ...
在这两种情况中,通过TLS,基因组的完整性和DNA复制的连贯性分别得以保持,但DNA损伤依然存在,需要在后续的修复过程中得到解决,因而TLS(以及HDGR)被认为是一种“损伤耐受机制(路径)”,简称DT机制(路径)-Damage Tolerance Mechanism(Pathway)。(15)(17)(18)(25-36)...