Also disclosed are methods of producing polyomavirus antigen-specific T cells by contacting mononuclear cells with a mixture of peptides from a polyomavirus antigen. The antigen-specific T cells or modified DCs may be administered to a subject to induce or enhance an immune response to polyomavirus...
Despite their key regulatory role and therapeutic potency, the molecular signatures of interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment remain poorly characterized. Here, we systematically characterize t
Type III interferon (IFN-λ) is important for innate immune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV) infection. However, the mechanisms by which IFN-λ programs adaptive immune protection against IAV are
secretion.These two kinds of cells may be valuable tools for modulating immunity in the setting of autoimmunity,cancer,chronic viral infections and graft rejection,etc.Here we discuss the current knowledge on the functions of regulatory T cells and denditic cells-based immunoregulation and the ...
C:Ex vivo expansion of depleted BM did not lead to generation of T cells (CD3+, CD4+, CD8+), B cells (CD19+), or NK cells (NK1.1+). D: Transduction of the eDCs with the gfp-luc dual function reporter, during the 1-week expansion resulted in a transduction efficiency of up to...
Purified migratory LCs or CD1c+DDCs were added in graded numbers to (a) allogeneic naive CD4+ or (b) both CD4+ and CD8+ T cells from the same donor. After 4 days of culture, 3H-thymidine was added, and cells were harvested 16 hours later. Results are the mean counts per minute (...
Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ (1997) The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 185(6):1101–1111 Article CAS PubMed PubMed Central Google Scholar Olweus J, BitMansour A, ...
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the good positive prognostic value of infiltrating CD81 T cells. Cancer Res 2014;74: 705-715... J Goc,C Germain,TKD Vobourgais,... - 《Cancer Research》 被引量: 9发表: 2013...
As GM-CSF induces tolerogenic dendritic cells (DCs) that in turn convert conventional T cells to Tregs, the pathways for DC induction of Tregs were assessed. Methods Following differentiation, bone marrow-derived dendritic cells (BMDCs) were cultured in media or GM-CSF with or without post-...
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microe