29、n and at other body surfaces. Professional antigen presenting cells in the skin include Langerhans cells (LCs) in the epidermis, and CD103+ and CD103- DCs in the dermis DENDRITIC CELL DEVELOPMENTDENDRITIC CELL DEVELOPMENT Origin of Conventional Dendritic Cells in the Lymphoid OrgansOrigin of ...
Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME).
TReg cells have multiple mechanisms at their disposal to mediate their suppressive effects. These can be grouped into four basic 'modes of action': suppression by inhibitory cytokines, suppression by cytolysis, suppression by metabolic disruption and suppression by modulation of dendritic-cell (DC) ma...
et al. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 180, 4706–4713 (2008). 9. Feng, B. S. et al. Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy ...
Plasmacytoid dendritic cells DLNs: Draining lymph nodes IAV: Influenza A virus MAIT cells: Mucosal-associated invariant T cells NKT cells: Natural killer T cells TCR: T cell receptor MR1: Major histocompatibility complex, class I-related gene protein αGC: α-Galactosylceramide iNKT: ...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
Dendritic cells DN: Double negative GALT: Gut associated lymphoid tissue HAA: 3-hydroxyanthranilate HGF: Hepatocyte growth factor HIV: Human immunodeficiency virus HLA: Human leukocyte antigen ICOS: Inducible T cell costimulator ICOSL: Inducible T cell costimulator ligand IDO: Indoleamine ...
The dendritic cell signaling knowledgebase is accessible at http://tsb.mssm.edu/pathwayPublisher/DC_pathway/DC_pathway_index.html.Background The innate immune system represents the first line of defense against attack by viral, bacterial, and parasitic infections. Dendritic cells (DCs), which are ...
G. The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev. Cell 14, 216–226 (2008). Article PubMed PubMed Central CAS Google Scholar Nakayama, M. et al. Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev. Cell...
(BECs, LECs and NESCs) and three contaminating haematopoietic cell components (lymphocytes, plasma cells and dendritic cells) on the uniform manifold approximation and projection (UMAP) (Fig.1b). Cell-type annotation was performed by analysing the expression levels of canonical gene markers (Fig.1...