Dendritic Cell Function After Gene Transfer with Adenovirus-calcium Phosphate Co-precipitatesreceptorGenesDendritic Cellscalcium phosphateAdenovirus Infections基因树突细胞Dendritic cells (DCs) are essential for initiating and directing antigen-specific T-cell responses. Genetic modification of DC is under study ...
Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells isto capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells(1). What are dendritic cell...
Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve canc
Dendritic cells are instrumental for the activation of naïve T cells or reactivation of T cells from the memory pool (McLellan et al.1996). T cell activation requires antigen presentation in MHC class I (for CD8+T cell) or II (for CD4+T cells) molecules (signal 1), in combination wi...
Summary. Dendritic cells (DCs) are likely to play a key role in the compromised T-cell function associated with hepatitis C Virus (HCV) infection. Howe... EJ Ryan,NJ Stevenson,JE Hegarty,... - 《Journal of Viral Hepatitis》 被引量: 42发表: 2011年 Dendritic cells and liver fibrosis...
Dendritic cells are known to express tissue factor19, and thera- peutic efficacy of hirudin implicated thrombin in a feedback loop that regulates dendritic cell function. Fibrin was detected in lymph- atic sinuses that were identified by LYVE-1 staining, confirming thrombin generation in this ...
(priming) phase of the immune response1,2. However, DCs were first observed in skin sections in the late 1800s by Paul Langerhans, who mistakenly identified them as a cell of neurological function3(Fig. 1a). Once it was realized that Steinman's DCs were related to Langerhans cells (LCs)...
Jenne L, Hauser C, Arrighi JF, Saurat JH, Hugin A: Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function. Gene Therapy 2000, 7: 1575–1583. ArticlePubMedCASGoogle Scholar ...
Leone P, Shin E-C, Perosa F, Vacca A, Dammacco F, Racanelli V (2013) MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells. J Natl Cancer Inst 105:1172–1187 Article CAS Google Scholar Lesimple T, Neidhard E-M, Vignard V, Le...
function. These changes have been mainly detected in blood, in cells infiltrating cancers and in lymphonodes (LNs). In addition, it has been documented that most chemotherapies deeply impair DC function, whereas the capability of patients T-cell to drive an effective immune response is comparable...