Because DCs are scattered in non‐lymphoid organs as immature cells, they must be activated to initiate primary antigen‐specific immune reactions. Therefore, we hypothesized that some simple chemicals must affect the function of DCs. In this paper, we first demonstrated that human monocyte‐derived...
Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve canc
Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells isto capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells(1). What are dendritic cell...
The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown. Here we showed that DC-biased precursors depended on the expression of the transcripti...
stimulation of naive T cells, due to an increase in MHC complexes, as well as costimulatory molecules, on the cell surface. This amplified exposure serves to direct effector function of responding T cells (Leslie et al., 2002). A larger amount of costimulation ensures a sufficient producti...
(non)lymphoid tissues and that the differentiation and function of each of these subsets is highly dependent on the interacting cells and mediators in the local microenvironment. So, while this chapter provides experimental settings to study the direct effects of food bioactives on DCs, one should ...
(note that positive isolation of cells can also be used when the downstream applications include cell culture, flow cytometry, or studying cell function, but then a positive isolation with bead release from the cells are required, by using e.g., FlowComp products or the Positive Isolation Kits...
Dendritic cells (DC) play a key role in initiating and maintaining immune responses. Since the discovery of DC by Ralph Steinman over 40 years ago [1] and the identification of their key function as mediators of T cell-mediated immune responses, there has been a major focus on the use of...
Introduction Dendritic cells (DCs) are bone marrow-derived leukocytes whose primary function is that of antigen capture and pre- sentation for the initiation of a primary immune response [1^ 3]. Given their pivotal role in antigen processing as well as their important role in tumor immunology [...
In addition to the Langerhans cells, the submucosal DCs of the GU tract express DC-SIGN (CD209), which is a C-type lec- tin with capability of binding to a variety of pathogens includ- ing HIV-1.79 Instead of being degraded in the lysosome, HIV-1 has usurped the function of DC-SIGN...