Dendritic cells (DCs) play two critical roles in T cell-mediated immune responses—they activate naïve T helper (T) cells; and they polarize activated T helper cells toward Tor Teffector cells. During early cognate DC–naïve T cell interaction, T cells rapidly express CD40L, which ...
Dendritic cell activation—bridging innate and adaptive immunity DCs continuously sample their environment and, in the absence of inflammatory signals, are thought to reinforce peripheral T cell tolerance [1,2]. Activation, or maturation, of DCs occurs when pathogen-associated...
Zika but not Dengue virus infection limits NF-κB activity in human monocyte-derived dendritic cells and suppresses their ability to activate T cells Dendritic cells play pivotal roles in the immune response to viral infection but are targeted by flaviviruses resulting in evasion of the host response...
Macrophage Cell Overview Monocyte Cell Overview Dendritic Cell Overview T Helper 1 Cells Overview T Helper 2 Cell Overview Regulatory T Cells Overview T Helper 17 Cells Overview T Follicular Helper Cell Overview Cytotoxic T Cell Overview Natural Killer Cells Ove...
dendritic cell (DC) populations was critical for the development of protective IAV-specific CD8+T cell responses. Mice lacking the IFN-λ receptor (Ifnlr1−/−) had blunted CD8+T cell responses relative to wild type and exhibited reduced survival after heterosubtypic IAV re-challenge. ...
which induce cell recruitment, and cytokines such as IL-1, IL-15, and TNF-α, which may activate or prime locally recruited cells. The consequences will be an appropriate proinflammatory response and the generation of effector and memoryT cells, polarized toward appropriate immune responses on fut...
secretion by dendritic cells stimulates T cell responses, particularly differentiation of Th1 cells that produce interferon-gamma and other pro-inflammatory cytokines (See “Th1/Th2 Differentiation” pathway). While IL-4 generally stimulates Th2 differentiation, the stimulation of Th2 cell formation by...
Peyer's Patches and spleens of both MVA and VV-immunized mice induced substantial IFN-γ production from an antigen-specific CTL line [27], although whether cell subsets other than DCs from the same lymphoid tissues could also be loaded with Ags and activate T cells was not tested in the ...
Cell. 2008, 133: 775-787. 10.1016/j.cell.2008.05.009 CAS PubMed Google Scholar Zheng Y, Rudensky AY: Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007, 8: 457-462. 10.1038/ni1455 CAS PubMed Google Scholar Curotto de Lafaille MA, Lafaille JJ: Natural and ...
LPSinducescostimulatoryactivityforCD4+TcellsonBlymphocytesandmacrophages(66),andtriggersmaturationandmigrationofDCinvivo (Regulationofdendriticcellnumbersandmaturationbylipopolysaccharideinvivo.J.Exp.Med.1996.184:1413–1424.)CpGmotif Similartolipopolysaccharide,i.s.CpG-ODNcausedupregulationofMHCclassII,CD40and...