Dendritic cells (DCs) play two critical roles in T cell-mediated immune responses—they activate naïve T helper (T) cells; and they polarize activated T helper cells toward Tor Teffector cells. During early cognate DC–naïve T cell interaction, T cells rapidly express CD40L, which ...
the Tht program is primed in tumor-draining lymph nodes by dendritic cells presenting tumor antigens, and that their function is important for harnessing the antitumor response of anti-PD-1 treatment. Our molecular and functional findings support the modulation of Tht–dendritic cell interaction check...
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a neoadjuvant anti-PD-1 trial in patients with hepatocellular carcinoma (HCC),
Interaction of dendritic cells with myco- bacteria: where the action starts. Immunol Cell Biol 2000; 78:318± 24.Demangel, C., and W. J. Britton. 2000. Interaction of dendritic cells with my- cobacteria: where the action starts. Immunol. Cell Biol. 78:318....
More recently, it has been shown that α-MSH also exerts a strong anti-inflammatory and immunosuppressive activity. To elucidate the mechanisms underlying α-MSH-induced immunosuppression, we investigated whether α-MSH affects dendritic cell/T cell communication, as especially this interaction has an ...
When the DCs are not themselves directly exposed to the antigen, and the transfer occurs across an antigen gradient, the DCs with secondarily acquired, processed antigen may be potent stimulators of primary T-cell activation; DCs may not, therefore, stimulate responses to antigens in their own ...
MHC peptide interacts with the T cell receptors, costimulatory molecules interact with T cell-expressed coreceptors, and cytokines are released to polarize the T-cell response [28], thus results in the allergic airway inflammation. The role of DCs in the secondary immune response is further ...
To gain more insight into regulatory patterns of dendritic cell signaling, we analyzed the network using graph-theory methods: bifan, feedforward and multi-input convergence motifs were enriched. This emphasis on activating control mechanisms is consonant with a network that subserves persistent and ...
Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disorder of the central nervous system characterized by infiltration of immun
Here we show a contrasting function for glucose in dendritic cells (DCs), as glucose represses the proinflammatory output of LPS-stimulated DCs and inhibits DC-induced T-cell responses. A glucose-sensitive signal transduction circuit involving the mTOR complex 1 (mTORC1), HIF1α and inducible ...