CXCR3 in T cell function. Exp. Cell Res. 317 (5), 620-631, URL 〈http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid 1/4 3065205&tool1/4pmcentrez&rendertype1/4 abstract〉.Groom, J. R., and Luster, A. D. (2011) CXCR3 in T cell function. Exp. Cell Res. 317, ...
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4+ T cells and effector CD8+ T ce...
OBJECTIVE - Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine (C-X-C motif) receptor 3 (CXCR3) participates in T-cell accumulatio...
In conclusion, this study demonstrates a novel mechanism of T cell recruitment and function in the absence of exogenous Ag stimulation. By documenting that the execution of innate immune function requires CXCR3+CD4+ T cells, it highlights the critical role of CXCR3 chemokine biology for the ...
The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functions in HSC are not fully
Donor T-cell function was analyzed by cytokine secretion. The severity of acute GVHD was assessed by histopathological analysis of intestine and liver, GVHD clinical scores, and survival after BMT. Results Significantly higher numbers of donor CD8+ CXCR3−/− T cells were found in the spleen...
T cell alpha chemoattractant (I-TAC) has been investigated in a label-free impedance-based cellular assay[64]. For this technique, low-voltage currents run through microelectrode sensors at the bottom of a plate to which cells are attached. Changes in impedance upon ligand addition are ...
摘要: The numbers of circulating CD4+,CXCR3+ and CD4+,CCR2+ T cells are selectively decreased during SLE flares. A decrease in the number of circulating CD4+ T cells expressing CCR2 and/or CXCR3 could serve as a biomarker of the SLE flare....
Objective Infiltrating lymphocytes have been demonstrated to play an important role in the tissue injury that occurs in systemic lupus erythematosus (SLE). Inflammatory chemokines control lymphocyte traffic through their interaction with T cell chemokine receptors. In this study we assessed the expression ...
We successfully constructed an engineered B16 cell line which constantly express the mouse CXCR3A gene.PartⅡStudy the migration and oncogenic function of B16-mCXCR3A cell line in vitro and in vivo:To investigate the role of the mouse gene CXCR3A in the process of tumor formation and ...