This antibody worked very well to measure CXCR3 expression on T cells and monocytes. Very little background or non-specific staining was detected on CXCR3-KO cells. DOI or PMID # N/A Additional Notes BioLegend recommends 1:20 dilution, but we've found it works well at 1:50 too....
CXCR3 expression on peripheral CD4 + T cells as a predictive marker of response to treatment in chronic hepatitis C[J] . Clinical Immunology . 2009 (1)CXCR3 expression on peripheral CD4+ T cells as a predictive marker of response to treatment in chronic hepatitis C. Perney P,Turriere C,...
Therefore, it is likely that CXCR3 expression on T cells mediates T cell migration to the lung in response to the inflammatory chemokines, and that in its absence, other chemokine receptor-ligands mediate this function. Furthermore, higher expression of CXCL9 was found to differentiate disease ...
However, CD8αCre-ALK5flox/flox (ALK5ΔCD8) mice reject tumors in high proportions, dependent on CD8+ T cells. ALK5ΔCD8 mice have more tumor-infiltrating effector CD8+ T cells, with more cytotoxic capacity. ALK5-deficient CD8+ T cells exhibit increased CXCR3 expression and enhanced ...
ceptors dist ribution in normal and inflamed tissues : Expression on ac2 tivated lymphocytes , endot helial cells , and dendritic cells [ J ] . L ab I nve , 2001 , 81 (3) : 4092418. [ 5 ] Kazuhiro K, Thomas EL , Stefan W, et al . Blocking chemokine re2 ...
Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients. (2011). Decreased CXCR3 Expression in CD4+ T Cells Exposed to Asbestos or Derived from Asbestos-exposed Patients. Am J Respir Cell Mol Biol, Vo.45,... M Maeda,Y Nishimura,H Hayashi,...
The expression of CCR5 and CXCR3, two chemokine receptors involved with homing of T cells to inflamed tissue, was examined longitudinally on CD4+ and CD8+ T cells in patients with a first demyelinating event of the central nervous system (CNS) randomized to receive i.m. injections of interfer...
In a mouse tumor model, the suppressive effect of CD8+ T cells on tumor growth was dependent on CXCR3 expression. Conclusion These findings illustrate that SCD not only orchestrates the differentiation of T helper cells, but also promotes the antitumor activity of CD8+ T cells, suggesting its ...
(ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-...
Once bystander-activated, memory CD8+T cells acquire an effector T cell-like phenotype, including expression of granzyme B4,5,7, and IFNγ2,6,8. The biological significance of acquiring cytotoxic effector function in the absence of cognate Ag was long unclear, until it was shown that bystander...