CSF1 overexpression has pleiotropic effects on microglia in vivo. Glia (2014) 62(12):1955-67. doi:10.1002/glia.22717De I, Nikodemova M, Steffen MD, Sokn E, Maklakova VI, et al. (2014) CSF1 overexpression has pleiotropic effects on microglia ...
CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE[J]. Front Cell Neurosci, 2019, 12: 523. 21. LUO J, ELWOOD F, BRITSCHGI M, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in...
tionofmicroglia,however,isstillunclear.Notably,althoughacti- vationofmicrogliawasreadilydemonstratedafterdamagetothe peripheralbranchoftheprimarysensoryneuron,microgliaappeared tobeunresponsivetotransectionofthecentralbranch,namelythe dorsalroot 10 (Fi .1a).Thus,injuredsensoryneuronsindorsalroot ...
20.WLODARCZYK A, BENMAMAR-BADEL A, CÉDILE O,et al. CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE[J]. Front Cell Neurosci, 2019, 12: 523. 21.LUO J, ELWOOD F, BRITSCHGI M, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured ...
小胶质细胞(microglia,MG)在中枢神经系统分布较广,约占胶质细胞的10%-20%,在神经元的生理活动中起着支持、营养、保护及修复等重要功能,是神经组织不可缺少的成分。MG... 周杰,章翔 - 《国际神经病学神经外科学杂志》 被引量: 8发表: 2005年 面神经离断伤后核团微环境中NG2阳性细胞及各类胶质细胞的反应 目...
Downstream of CSF1R, we found that the microglial membrane adapter protein DAP12 is required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglia proliferation. Thus, both CSF1 and DAP12 are potential targets...
Additionally, in contrast to in vitro findings in macrophages, in vivo CSF1 over-expression does not induce an M2 polarized phenotype in normal microglia or in GAMs. We have also developed a transgenic system to over-express CSF1R in a tissue specific manner and are employing it to study ...
MicrogliaAstrogliosisOligodendrogenesisColony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previously showed that CSF1 overexpression in the CNS ...
QRT-PCR showed the IL-1, TNF-伪 and BDNF were simultaneously upregulated in the activated microglia cells, whereas the specific AMPK inhibitor compound C exhibited reverse effects in microglia. Using immunofluorescence staining and electron microscopy, we found CSF1 decreased microglial p62 expression ...
microgliaCsf1remyelinationosteopetrotic miceRemyelination, a highly efficient central nervous system (CNS) regenerative process, is performed by oligodendrocyte progenitor cells (OPCs), which are recruited to the demyelination sites and differentiate into mature oligodendrocytes to form a new myelin sheath...