Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young bra... XG Luo,JQ Ding,SD Chen - 《Molecular Neurodegeneration》 被引量: 332发表: 2010年 Metallothionein reduces central nervous system inflammation...
Microglia across the lifespan: from origin to function in brain development, plasticity and cognitionMicroglia are the only immune cells that permanently reside in the central nervous system (CNS) alongside neurons and other types of glial cells. The past decade has witnessed a revolution in our ...
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activ
Microglia - insights into immune system structure, function, and reactivity in the central nervous system. 来自 Semantic Scholar 喜欢 0 阅读量: 46 作者:Wirenfeldt M,Babcock AA,Vinters HV 摘要: Microglia are essential cellular components of a well-functioning central nervous system (CNS). The ...
Microglia interact with almost all CNS components during embryonic and postnatal development, when they carry out a large number of non-immune tasks that are crucial for brain function. Microglia have multidimensional activation states in CNS diseases and injuries, such that these cells can have benef...
Normally, TREM2 activation promotes chemotaxis, phagocytosis, proliferation, and maintenance activities of microglia that are essential to their neuroprotective function. More specifically, normal TREM2 ligand binding will lead to PI3K and downstream mTOR activation, which inhibits microglial autophagy, a ...
Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably...
function of the mobility from 59 eV at 1/K0 = 1.6 Vs cm-2 to 20 eV at 1/K0 = 0.6 Vs cm-2. The acquired diaPASEF raw files were searched with the UniProt Human proteome database in the DIA-NN search engine with default settings of the library-free search algorithm 31,768...
These data suggest that FLT-3 is involved in microglial cells' capacity to respond to environmental cues to function as antigen presenting cells and mediate CNS inflammation. Furthermore these data suggest that FLT-3 may be a therapeutic target on microglia to mitigate CNS inflammation. 展开 关键...
Understanding the physiological functions of these cells is crucial to determining their roles in disease. Here we focus on recent developments in our rapidly expanding understanding of the function, as well as the dysfunction, of microglia in disorders of the CNS. This is a preview of ...