The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called ‘degeneration- or...
Describe the function of microglia.Neuroglia Cells of the Central Nervous System (CNS):Neuroglia cells are the non-excitable cells that mainly act as supporting cells of the nervous system. They are found in the central nervous system (CNS) as well as in the peripheral nervous system (PNS)...
Microglia:Neuroprotective and Neurotrophic Cells in the Central Nervous System. Microglia are currently accepted as sensor cells in the central nervous system that respond to injury and brain disease.The main function of microglia is b... Nakajima,Kazuyuki,Kohsaka,... - 《Current Drug Targets Cardi...
Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18, 965–977 (2015). CAS PubMed PubMed Central Google Scholar Hoban, A. E. et al. The microbiome regulates amygdala-dependent fear recall. Mol. Psychiatry 23, 1134–1144 (2018). CAS Pub...
The origin and function of the increased of "atypical lymphocytes" which appear in the blood of patients with many inflammatory diseases is not known. Leuk... DA Horwitz - 《Journal of Clinical Investigation》 被引量: 40发表: 1972年 Influence of the macrophage bacterial resistance gene Nramp1 ...
It is important to note that the function of these cells is more complex than originally conceived, as there is increasing evidence that microglial responses can vary greatly among individuals. Here, this review will describe the changing behavior of microglia from development and birth through to ...
Fig. 2. The function of cerebralVAMand PVMs in physiology and pathology. Since they contact direactly with cerebral vessels,VAMand PVMs are determined to implicate inangiogenesisand maintenance,phagocytosis, andblood flowregulation. However, due to their different morphologies, signatures and locations...
Related to microglia:Astrocytes,Oligodendrocytes mi·cro·gli·a (mī′krō-glē′ə, -glī′-) pl.n. Small neuroglial cells of the central nervous system that have long processes and act as phagocytes at sites of neural damage or inflammation, destroying pathogens and damaged cells. ...
Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18:965–77. Mudd AT, Berding K, Wang M, Donovan SM, Dilger RN. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes...
et al. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 346, 89–93 (2014). Article CAS PubMed PubMed Central Google Scholar Norden, D. M. & Godbout, J. P. Review: microglia of the aged brain: primed to be activated and ...