Microglia function in the normal brain[J]. Adv Exp Med Biol, 2016, 949:67 -92.von Bernhardi, R., Heredia, F., Salgado, N., and Munoz, P. (2016). Microglia function in the normal brain. Adv. Exp. Med. Biol. 949, 67-92. doi: 10.1007/ 978-3-319-40764-7_4...
In addition to the pathological aspects, secretory factors that showed neurotrophic effects were described with special reference to their physiological significance in the neuronal growth, neuronal function and regeneration processes. Accumulated evidence suggests that microglia are associated with not only ...
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called ‘degeneration- or...
Microglia in the aging brain: relevance to neurodegeneration Microglia cells are the brain counterpart of macrophages and function as the first defense in the brain. Although they are neuroprotective in the young bra... XG Luo,JQ Ding,SD Chen - 《Molecular Neurodegeneration》 被引量: 331发表: ...
we ran standard normalization using the SCTransform function in the Seurat R package, followed by dimensionality reduction using 40 PCs, and then integrated the two data sets (iMGs and post-mortem nuclei) using the Harmony package with theta = 4 and lambda = 0.05. UMAP representations...
The function of resting microglia has not been fully elucidated, but they may release low levels of growth factors that support the survival of neurons and glia. Recent in vivo imaging studies demonstrate that microglia actively monitor the CNS parenchymal environment by continual movement of their ...
Sleep drives metabolite clearance from the adult brain. Science 342, 373–377 (2013).4. Colonna, M. & Butovsky, O. Microglia function in the central nervous system during health and neurodegeneration. Annu. Rev. Immunol. 35, 441–468 (2017).5. Bohlen, C. J., Friedman, B. A., De...
There is compelling evidence to support the idea that autophagy has a protective function in neurons and its disruption results in neurodegenerative disord... M Alirezaei,WB Kiosses,CT Flynn,... - 《Plos One》 被引量: 213发表: 2008年 Primary Phagocytosis of Neurons by Inflamed Microglia: Poten...
inbrain function, health, and disease. The cells are also gaining increased attention for their roles in assembling and maintainingneural circuits, and how they are able to change their molecular identity to match their environment. To neuroscientists, the mystery has long been how they make this...
Understanding the physiological functions of these cells is crucial to determining their roles in disease. Here we focus on recent developments in our rapidly expanding understanding of the function, as well as the dysfunction, of microglia in disorders of the CNS. This is a preview of ...