Microglia function in the normal brain[J]. Adv Exp Med Biol, 2016, 949:67 -92.von Bernhardi, R., Heredia, F., Salgado, N., and Munoz, P. (2016). Microglia function in the normal brain. Adv. Exp. Med. Biol. 949, 67-92. doi: 10.1007/ 978-3-319-40764-7_4...
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called ‘degeneration- or...
Microglia exist in different morphological forms in the developing brain. They show a small cell body with scanty cytoplasm with many branching processes in the grey matter of the developing brain. However, in the white matter such as the corpus callosum where the unmyelinated axons are loosely or...
The function of resting microglia has not been fully elucidated, but they may release low levels of growth factors that support the survival of neurons and glia. Recent in vivo imaging studies demonstrate that microglia actively monitor the CNS parenchymal environment by continual movement of their ...
Sleep drives metabolite clearance from the adult brain. Science 342, 373–377 (2013).4. Colonna, M. & Butovsky, O. Microglia function in the central nervous system during health and neurodegeneration. Annu. Rev. Immunol. 35, 441–468 (2017).5. Bohlen, C. J., Friedman, B. A., De...
The prominence of microglia priming in the white matter tracts of the brain suggests that the axons might be primarily affected by the accumulation of DNA damage. The exact mechanism by which DNA damage accumulation affects axonal function is yet to be worked out. However, a possible mechanism ...
Microglia are resident myeloid cells of the central nervous system (CNS), activated in the brains of various neurological diseases. Microglia are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions. However, a lack of specific ...
Extracellular nucleotides, including ATP, have been demonstrated to transmit important physiological signals in the brain through either G-protein-coupled ... Y Sasaki,M Hoshi,C Akazawa,... - 《Glia》 被引量: 359发表: 2003年 P2Y12 expression and function in alternatively activated human microglia...
Microglia:Neuroprotective and Neurotrophic Cells in the Central Nervous System. Microglia are currently accepted as sensor cells in the central nervous system that respond to injury and brain disease.The main function of microglia is b... Nakajima,Kazuyuki,Kohsaka,... - 《Current Drug Targets Cardi...
Microglia interact with almost all CNS components during embryonic and postnatal development, when they carry out a large number of non-immune tasks that are crucial for brain function. Microglia have multidimensional activation states in CNS diseases and injuries, such that these cells can have benef...