The emission tomographic imaging of activated microglia in the brain moves into the focus of neuroscientific research with increasing recognition of contributions of early inflammatory processes to neurodegenerative, traumatic, cancerous and infectious diseases of the brain. Whereas the mitochondrial isoform ...
states in human microglia. These transcriptional states are determined by their spatial distribution, and they further change with aging and brain tumor pathology. This description of multiple microglia phenotypes in the human CNS may open promising new avenues for subset-specific therapeutic interventions...
Here, we briefly review topics covered in our 2011 Society for Neuroscience minisymposium "The Role of Microglia in the Healthy Brain." This summary is not meant to be a comprehensive review of microglia physiology, but rather to share new results and stimulate further research into the cellular...
Finch CE, Morgan TE, Rozovsky I, Xie Z, Weindruch R, Prolla T. Microglia and Aging in the Brain. In: Streit WJ, ed. Microglia in the Regenerating and Degenerating Central Nervous System. ...
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged ...
A neurodevelopmental process in which axons that travel in the same direction often adhere together to form a tight bundle. Corpus callosum A thick bundle of nerve fibres that connect the left and right hemispheres of the brain and form the most prominent white-matter structure. ...
18, Pages 598: Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and neurodegeneration. In the brain, it has mostly been studied in neurons,... PlazaZabala,Ainhoa,SierraTorre,... 被引量: 46...
Therefore, our studies examined the immune response by microglia in the spinal cord compared to the immune response by microglia in the brain. Microglia in the spinal cord of mice expressed higher levels of surface immune molecules than microglia in the brain, and upon virus infection, microglia ...
Contemporaneously, diverse roles are emerging for microglia in the healthy brain, from sculpting developing neuronal circuits to guiding learning-associated plasticity. Understanding the physiological functions of these cells is crucial to determining their roles in disease. Here we focus on recent ...
Microglia proliferate extensively during the subacute phase of SCI Under normal circumstances, the adult microglial population remains stable in the brain throughout life by coupled cell death and cell proliferation4, but little is known about its dynamic in the spinal cord and how it reacts followi...