The AD brain is characterized by the presence of Amyloid-β (Aβ) plaques, neurofibrillary tangles, and an increased inflammatory response. Microglia, the chief immune cells of the central nervous system, have been implicated in AD due to their strong association with Aβ plaques. The role of...
Finch CE, Morgan TE, Rozovsky I, Xie Z, Weindruch R, Prolla T. Microglia and Aging in the Brain. In: Streit WJ, ed. Microglia in the Regenerating and Degenerating Central Nervous System. ...
states in human microglia. These transcriptional states are determined by their spatial distribution, and they further change with aging and brain tumor pathology. This description of multiple microglia phenotypes in the human CNS may open promising new avenues for subset-specific therapeutic interventions...
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called ‘degeneration- or...
TMEM119-positive microglia did not consistently express polarized markers for M1 (CD80) or M2 (CD163, CD209) in AD brains. These results suggest that TMEM119 serves as a reliable microglial marker that discriminates resident microglia from blood-derived macrophages in the human brain. 展开 关键...
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain Pessac B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res 1999; 117:145-... F Alliot,I Godin,B Pessac - 《Deve...
Therefore, our studies examined the immune response by microglia in the spinal cord compared to the immune response by microglia in the brain. Microglia in the spinal cord of mice expressed higher levels of surface immune molecules than microglia in the brain, and upon virus infection, microglia ...
Satoh M, Shimad A, Hosokaw M (2007) Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse... N Kumagai,Y Chiba,M Hosono,... - 《Brain Research》 被引量: 68发表: 2007年 Microglia and synapse: interactions in health and neuro...
Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat...
We analyzed Nrf2 activation and the resulting accumulation in post-ischemic rat brain cells using double immunofluorescence staining with antibodies directed against Nrf2 and cell type-specific markers. The core infarct region showed no obvious positive staining signal for Nrf2 24h after the initiation ...