The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these activated cells have been called ‘degeneration- or...
These reactive microglia has been thought to function as a scavenger or antigen presenting cells. Also, in vitro system have shown that microglia have the potential to produce a large variety of physiologically active substance such as cytokines, growth factors, and other materials. Some of factors...
The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease Microglia are a self-sustained population of immune/myeloid cells present throughout the central nervous system (CNS). Microglia are in a "resting... Shlomo,Rotshenke...
Glial cells in neurotoxicity Neuroglial cells of the central nervous system include the astrocytes, oligodendrocytes, and microglia. Their counterparts in the peripheral nervous system... M Aschner,JW Allen,HK Kimelberg,... - 《Annual Review of Pharmacology & Toxicology》 被引量: 148发表: 1999...
It is becoming increasingly apparent that microglia, the immune cells of the CNS, and their peripheral counterparts, macrophages, have a major role in normal physiology and pathology. Recent technological advances in the production of particular cell typ
Microglia, the resident immune cells of the central nervous system (CNS), play an important role in CNS homeostasis during development, adulthood and agein... VH Perry,J Teeling - 《Seminars in Immunopathology》 被引量: 332发表: 2013年 Immune regulation within the central nervous system The ...
For many years the function of microglia was unclear. However, today it is known that these cells mediate immune responses in the central nervous system by acting as macrophages, clearing cellular debris and dead neurons from nervous tissue through the process of phagocytosis (cell eating)....
Microglia, the immune cells of the central nervous system, take part in brain development and homeostasis. They derive from primitive myeloid progenitors that originate in the yolk sac and colonize the brain mainly through intensive migration. During development, microglial migration speed declines which...
[Structure and function of the central nervous system]. The main elements of the central nervous system are the brain and the spinal cord. It contains millions of neurons and glial : astrocytes, oligodendrocytes, and microglia. The main role of the CNS is to process information, analyze signa...
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC...