Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded ...
Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably...
A milieu molecule for TGF-β required for microglia function in the nervous system. Cell 174, 156–171.e16 (2018). CAS PubMed PubMed Central Google Scholar Wong, K. et al. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Nat. Immunol. 18, 633–641...
A. et al. TNF-α/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron 82, 587–602 (2014). Article CAS PubMed PubMed Central Google Scholar Binshtok, A. M. et al. Nociceptors are interleukin-1β sensors. J. Neurosci. 28, 14062–14073 (2008)...
A century after Cajal identified a “third element” of the nervous system, many issues have been clarified about the identity and function of on
Microglia - insights into immune system structure, function, and reactivity in the central nervous system.喜欢 0 阅读量: 42 作者:Wirenfeldt,M,Vinters,HV,Babcock,AA 摘要: Microgliare essentialellularomponentsf well-functioningentral nervousystem (CNS).he developmentnd establishmentfheicroglial ...
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged ...
Due to the different origins of these two cell types, it is important to distinguish their role and function in the development and progression of these diseases. In this review, we will summarize and discuss the current knowledge of the differential contributions of microglia and monocytes in ...
Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the peripheral nervous system (PNS). Here, by comparing gene expression across neural and conventional tissue-resident macrophages, we identified trans...
Thus, despite traditional classifications of microglia as immune cells first, mounting data indicate that they are intricately entwined in the complex process of brain tissue development and adult brain homeostasis, interacting with virtually every cell type in the brain to orchestrate non-immune as ...