Proper development and function of the mammalian central nervous system (CNS) depend critically on the activity of parenchymal sentinels referred to as microglia. Although microglia were first described as rami
and their numbers varied greatly, ARG1+microglia number in the BF/vStr was notably reduced from P10 to P28 (Fig.1c), while at P100, only a residual population could be observed (Extended Data Fig.2b,c). Of note, early postnatal life is a critical period for brain development, during wh...
2. The changes in drug development strategies for AD 3. The dual role of microglia in the progression of AD 4. The complex relationship between AD pathological marker Aβ peptides and microglia 5. Regulation of microglia function by small molecule compounds 6. Conclusions and perspectives Funding...
Environment matters: microglia function and dysfunction in a changing worldThe immune system is our interface with the environment, and immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal brain development. This...
The role of lactate in the control of microglial function remains poorly investigated. Here, the authors show that lactate promotes lysosomal acidification in microglia, and that mice lacking the lactate transporter MCT4 in these cells display defective brain development and anxiety-like behavior. ...
A century after Cajal identified a “third element” of the nervous system, many issues have been clarified about the identity and function of one of its major components, the microglia. Here, we review recent findings by microgliologists, highlighting results from imaging studies that are helpi...
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged ...
Immune function of microglia 来自 EBSCO 喜欢 0 阅读量: 128 作者: F Aloisi 摘要: During the past decade, mechanisms involved in the immune surveillance of the central nervous system (CNS) have moved to the forefront of neuropathological research mainly because of the recognition that most ...
The primary function of this system is to p... WJ Streit,JR Conde,SE Fendrick,... - 《Neurological Research》 被引量: 560发表: 2005年 The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease An unexpected role for the classical complement cascade in the ...
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