In this study, we found that microglia-specific knock-down of the core clock gene,, resulted in increased microglial phagocytosis in mice subjected to high-fat diet (HFD)-induced metabolic stress and likewise among mice engaged in critical cognitive processes. Enhanced microglial phagocytosis was ...
Recently it has been shown that mRNA of Iba1 (ionized calcium binding adaptor molecule 1), which was a novel calcium binding protein cDNA-cloned by our group, is specifically expressed in microglia in cultures of rat brain cells [Imai et al. Biophys. Biochem. Res. Commun., 224 (1996) ...
摘要: Adeno-associated virus (AAV)-mediated genetic targeting of microglia remains a challenge. Overcoming this hurdle is essential for gene editing in the central nervous system (CNS). Here, we characterized the minimal/native promoter of the关键词:...
Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. J. Neurochem. 94: 1546-1558.Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y. Microglia- specific expression of microsomal prostaglandin E2...
Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation Pedram Honarpisheh, Juneyoung Lee, Anik Banerjee, Maria P. Blasco-Conesa, Parisa Honarpisheh, John d’Aigle, Abdullah A. Mamun, Rodney M. Ritzel, Anjali Chauhan, Bha...
microglia, the brain’s resident immune cells, are an attractive target for potentially more effective therapeutic strategies. However, there is no current in vitro model system that captures AD patient-specific microglial characteristics using physiologically relevant and experimentally flexible culture condi...
Previously, we have shown that either disruption of the Hoxb8 gene or ablation of a microglial subpopulation, Hoxb8 microglia, results in mice exhibiting both chronic anxiety and OCSD-like behavior, compulsive pathological hair pulling (trichotillomania)
MICROGLIAThis document is a correction notice for an article titled "Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease" published in the Journal of Neuroinflammation. The correction addresses an error in the "Availability of data and...
In order to further establish that hiMG displayed a microglia-specific signature, we constructed a Nanostring array based on genes reported to be unique or highly enriched in global gene expression analyses of primary microglia acutely isolated from patients undergoing non- tumor brain surgery as ...
We describe that microglia and other macrophages express in principal a similar profile of inflammasome proteins and both cell types can form inflammasomes. However, we found important cell type-specific differences, pertaining to differences in the kinetics of inflammasome-mediated response, inflammatory ...