Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, Franciszkiewicz K, Chouaib S, Kaminska B (2008) Microglia-derived TGF-beta as an important regulator of glioblastoma invasion—an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II ...
Herein, using cell-type-specific conditional or iKO models of theTgfb1gene, we demonstrate that microglia- but not neuron- or astrocyte-derived TGF-β1 ligand is required for the maintenance of homeostatic microglia in the early postnatal and adult brain. Furthermore, the loss of microglia-deriv...
The results showed that only transforming growth factor beta (TGF-β) caused an increase in the in vitro proliferation of both microglial cell lines. It has been reported that colony-stimulating factor 1 promotes the proliferation of microglia, while TGF-β promotes both proliferation and inhibition...
TGFbeta1 inhibits IFNgamma- mediated microglia activation and protects mDA neurons from IFNgamma- driven neurotoxicity. J. Neurochem. 134, 125-134.Zhou, X., Zoller, T., Krieglstein, K., et al., 2015. TGFβ1 in- hibits IFNγ-mediated microglia activation and protects mDA neurons from ...
Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci. 2014;17(1):131–43. Article CAS PubMed Google Scholar Picelli S, Bjorklund AK, Faridani OR, Sagasser S, Winberg G, Sandberg R. Smart-seq2 for sensitive full-length transcriptome ...
is involved in microglial surveillance functions and is also considered a specific marker for resting microglia. To the current knowledge, the most specific microglia markers are TMEM119 and P2RY12. Additionally, hexosaminidase subunit beta (HEXB) has been identified as a specific marker for microglia...
antigen-presenting cells (APCs) functions, and blood–brain barrier (BBB) permeabilization [42]. M2 microglia express IL-4, IL-10, IL-13, brain-derived neurotrophic factor (BDNF), and TGF-β and participate in wound healing, anti-inflammatory response, phagocytosis of debris, and ECM protectio...
Microglial features in steady-state. In steady-state, microglia are maintained via paracrine colony-stimulating factor-1 receptor (CSF1R) signaling and via autocrine transforming growth factor-β (TGFβ) signaling. The two pathways endow a unique homeostatic feature of microglia, characterized by high...
Microglia are the major source of TNF-alpha and TGF-beta1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem Int. 63, 47–53 (2013). Article CAS PubMed Google Scholar Wang, X. et al. LRG1 promotes angiogenesis by modulating endothelial TGF-...
Interleukin 1 beta IL6: Interleukin 6 Tgfbr1: Transforming growth factor-bete receptor type 1 Tgfb1: Transforming growth factor beta-1 NF-kb: Nuclear factor kb Igfr1: Insulin like growth factor 1 receptor Fgf: Fibroblast growth factor