Additionally, in contrast to in vitro findings in macrophages, in vivo CSF1 over-expression does not induce an M2 polarized phenotype in normal microglia or in GAMs. We have also developed a transgenic system to over-express CSF1R in a tissue specific manner and are employing it to study ...
CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE[J]. Front Cell Neurosci, 2019, 12: 523. 21. LUO J, ELWOOD F, BRITSCHGI M, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in...
inducedmicrogliaactivationorprolifera- tion 13 .Neuregulin-1(NRG-1)hasalsobeenimplicated,butNRG-1 isnotinducedinsensoryneuronsafternerveinjury 15 .Anotherview holdsthatATPreleasedafternerveinjurybindstothemicroglial P2X4purinergicreceptortoinitiatemicrogliaactivation 6,16 .However, nerveinjury–inducedmicroglia...
A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia Microglia are resident mononuclear phagocytes that play a principal role in the maintenance of normal tissue homeostasis in the central nervous system (CNS... JI Satoh,N Asahina,S Kitano,... - 《Gene Regulation &...
et al. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat. Commun. 13, 843 (2022). Article CAS PubMed PubMed Central Google Scholar Li, Z. et al. M-CSF, IL-6, and TGF-...
Triggering receptor expressed on myeloid cells-2 (TREM2) and colony-stimulating factor 1 receptor (CSF1R) are crucial molecules for microgliopathy, which is characterized by microglia dysfunction and has recently been proposed as the neuropathological hallmark of neurological disorders. TREM2 and C...
Downstream of CSF1R, we found that the microglial membrane adapter protein DAP12 is required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglia proliferation. Thus, both CSF1 and DAP12 are potential targets...
Microglia are the innate immune cells of CNS; their proliferation, activation, and survival in pathologic and healthy brain have previously been shown to be highly dependent on CSF1R. Methods Here, we investigate the impact of such receptor on AD etiology and microglia. We deleted CSF1R using ...
MicrogliaAstrogliosisOligodendrogenesisColony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previously showed that CSF1 overexpression in the CNS ...
microgliaCsf1remyelinationosteopetrotic miceRemyelination, a highly efficient central nervous system (CNS) regenerative process, is performed by oligodendrocyte progenitor cells (OPCs), which are recruited to the demyelination sites and differentiate into mature oligodendrocytes to form a new myelin sheath...