Additionally, in contrast to in vitro findings in macrophages, in vivo CSF1 over-expression does not induce an M2 polarized phenotype in normal microglia or in GAMs. We have also developed a transgenic system to over-express CSF1R in a tissue specific manner and are employing it to study ...
(NRG-1)hasalsobeenimplicated,butNRG-1isnotinducedinsensoryneuronsafternerveinjury15.AnotherviewholdsthatATPreleasedafternerveinjurybindstothemicroglialP2X4purinergicreceptortoinitiatemicrogliaactivation6,16.However,nerveinjury–inducedmicrogliaactivationisintactinP2X4knockoutmice17,andthesourceofATPafternerveinjurythat...
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia Nat. Immunol., 13 (2012), pp. 753-760 CrossrefView in ScopusGoogle Scholar Wei et al., 2005 S. Wei, D. Lightwood, H. Ladyman, S. Cross, H. Neale, M. Griffiths, R. Adam...
Triggering receptor expressed on myeloid cells-2 (TREM2) and colony-stimulating factor 1 receptor (CSF1R) are crucial molecules for microgliopathy, which is characterized by microglia dysfunction and has recently been proposed as the neuropathological hallmark of neurological disorders. TREM2 and C...
MicrogliaAstrogliosisOligodendrogenesisColony-stimulating factor 1 (CSF1) expression in the central nervous system (CNS) increases in response to a variety of stimuli, and CSF1 is overexpressed in many CNS diseases. In young adult mice, we previously showed that CSF1 overexpression in the CNS ...
QRT-PCR showed the IL-1, TNF-伪 and BDNF were simultaneously upregulated in the activated microglia cells, whereas the specific AMPK inhibitor compound C exhibited reverse effects in microglia. Using immunofluorescence staining and electron microscopy, we found CSF1 decreased microglial p62 expression ...
microgliaCsf1remyelinationosteopetrotic miceRemyelination, a highly efficient central nervous system (CNS) regenerative process, is performed by oligodendrocyte progenitor cells (OPCs), which are recruited to the demyelination sites and differentiate into mature oligodendrocytes to form a new myelin sheath...
CSF1 overexpression has pleiotropic effects on microglia in vivo. Glia (2014) 62(12):1955-67. doi:10.1002/glia.22717De I, Nikodemova M, Steffen MD, Sokn E, Maklakova VI, Watters JJ, et al. CSF1 overexpression has pleiotropic effects on microglia in vivo. Glia 2014;62:1955-67....
Drug-induced colony-stimulating factor 1 receptor (CSF1R) blockage is now a commonly used tool to cause reversible microglia depletion in mice. However, microglial depletion is not complete with a remaining fraction of approximately 5% of the original microglia. In order to characterize this ...
CSF1CSF1RPLCG2NeuroinflammationMicrogliaTemporal expression of endogenous p-CSF1R, CSF1R, CSF1, p-PLCG2, p-PKCε, and p-CREB in the ipsilateral hemisphere brain after HI. Representative western blot bands of the time course. Western blot data analysis showed that endogenous expression levels ...