This invention relates to an isolated nucleic acid fragment encoding a chromatin associated protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the chromatin associated protein, in sense or antisense orientation, wherein expression of the chimeric ...
但是,在人类基因组中编码的1,600多种转录因子中,只有一小部分被检测了。 这篇文章作为ENCODE项目的一部分,使用人类使用人类Hepg2细胞系中的208个染色质相关蛋白质(CAP)进行高通量测序,然后对得到的染色质免疫沉淀数据进行处理和分析。本文旨在尽可能完整的概述这种细胞类型的基因调控网络。 二、数据来源 ...
Nuclear proteins of tumors 1983, International Journal of Biochemistry Identification of a nuclear antigen with molecular weight of 48 000 differentially expressed in tumour and normal cells 1990, Cell Biochemistry and Function The characterization of non‐histone proteins whose amounts increase in chromat...
Chromatin-associated non-histone proteins of the sea urchin embryo are heterogeneous, and undergo qualitative as well as quantitative changes throughout early development. The rate of synthesis of these proteins is fairly constant to the pluteus stage and, in contrast to histone synthesis, does not ...
Cell surface proteins and malignant transformations Biochim. Biophys. Acta (1976) R.O. Hynes et al. Relationships between fibronectin (LETS protein) and actin Cell (1978)View more references Cited by (60) Structure of the pericellular matrix: Association of heparan and chondroitin sulfates with fi...
High-mobility-group (HMG) proteins are small and relatively abundant chromatin-associated proteins, which act as architectural factors. In plants, two groups of chromosomal HMG proteins have been identified, namely the HMGA family, typically containing four A/T-hook DNA-binding motifs, and the HMGB...
The major focus of my current research is to study the post-translational modification of the proteins especially histone associated proteins and their potential roles in rendering cancer cells resistant to the therapeutic treatments. Interference with this alteration could result in the identification of...
H-NS is one of the two most abundant proteins in the bacterial nucleoid and influences the expression of a number of genes. We have studied the interaction of H-NS with DNA; purified H-NS was demonstrated to constrain negative DNA supercoils in vitro. This provides support for the hypothesi...
The proteins were resolved on SDS-polyacrylamide gel electrophoresis gels and transferred to polyvinylidene fluoride membrane (Immobilon-P, Millipore-Sigma). After blocking with 5% non-fat dry milk for 1 h at room temperature, primary antibody was added at 4 °C and left overnight. After ...
ATRX belongs to the SNF2 family of proteins, many of which have been demonstrated to have chromatin remodeling activity. Constitution mutations in the X-encoded gene give rise to alpha thalassemia mental retardation (ATR-X) syndrome and a variety of related conditions that are often associated wit...