Overall, these results suggest a model in which Set4 is a stress-responsive, chromatin-associated protein that activates gene expression programs required for cellular protection against oxidative stress. This work advances our understanding of mechanisms that protect cells during oxidative stress and ...
Under a Creative Commons license open accessHeterochromatin protein 1α (HP1α) is involved in regulation of chromatin plasticity, DNA damage repair, and centromere dynamics. HP1α detects histone dimethylation and trimethylation of Lys-9 via its chromodomain. HP1α localizes to heterochromatin in ...
chromatin remodeling complexes38, other studies have shown that BRD4L also acts as a repressor, for example of the HPV-encoded E6 gene and autophagy genes by recruitment of histone methyltransferase G9A39,40. Conceivably, a BRD4/G9A interaction is also involved in the repression of p53 target ...
S7a. (c) Chromatin immunoprecipitation (ChIP) analysis of HP1 occupancy at cup, nos, piwi and vasa genes in newly eclosed female ovaries. The RNase sensitivity of this association was tested by pretreating the extract with a combination of RNase A and RNase T1 (right panel). Het-A was ...
UM:葡萄膜黑色素瘤,uveal melanoma;CUT&Tag:目标下切割和标记,Cleavage Under Targets and Tagmentation;No.:编号,number;rep,重复replicate;METTL14:甲基转移酶样14;IGV:综合基因组学查看器;NC:对照组normal control;H3K27Ac:组蛋白3在赖氨酸27处乙酰化;ChIP:染色质免疫沉淀Chromatin immunoprecipitation;qPCR:定量实...
Background MeCP2, methyl-CpG-binding protein 2, binds to methylated cytosines at CpG dinucleotides, as well as to unmethylated DNA, and affects chromatin c... CR Jordan,HL Hong,HC Kwan,... - 《Bmc Medical Genetics》 被引量: 154发表: 2007年 A novel type of replicative enzyme harbouring...
Heterochromatin protein 1 (HP1): interactions with itself and chromatin components 2020, Biophysical Reviews Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain 2020, PLoS ONE View all citing articles on ...
The more open chromatin configuration of AHR KO epithelial cells during differentiation could reflect the increased representation of Ap-1 which is involved in regulating chromatin dynamics60. Indeed, AHR activation can restrict Ap-1 activity in a cell -type dependent manner61,62,63. Furthermore, ...
Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration 15 November 2024 Main Cellular reprogramming consists of the loss of differentiated cell identity followed by the acquisition of embryonic stem pluripotency, which can be achieved by the...
Succinylation is a post-translational protein acylation modification that converts the cationic lysine side chain to an anion with large potential impacts on protein structure and function. Here we characterize the epigenome-wide distribution of succinyllysine marks in chromatin using chromatin immunoprecipit...