The gray-shaded area in g indicates a domain with a developmentally regulated gene; the orange-shaded region contains housekeeping genes. Full size image Cell fate along the dorsoventral axis is controlled by the nuclear concentration of the transcription factor Dorsal (Dl)57,58, which peaks ...
DNA binding proteins carry out important and diverse functions in the cell, including gene regulation, but identifying these proteins is technically challenging. In the present study, we developed a technique to capture DNA-associated proteins called rev
we performed an iterative peak calling and clustering method to parse out the distinct cell populations. In brief, we called peaks on aggregated reads for all cells, scored individual cells for insertion events in these reference peaks, and then carried out dimensionality reduction and cluster identi...
Interestingly, for all ATAC/RNA-seq co-clusters we observed enrichment of at least one predicted AP2 motif (in total, 16 motifs predicted for 13 different AP2 proteins; blue font in Figure 5B), suggesting that the corresponding AP2 TF is likely relevant in regulating these genes. ...
Pellet fraction contains the majority of protamine protein, while supernatant carries the majority of histone proteins. (B) Aggregation plot of data from Hammoud et al. (2009) (H. sapiens) and Erkek et al. (2013) data sets (M. musculus) aligned by TSS. (C) Aggregation plot of MNase ...
and promoters by regulating chromatin accessibility and the ability of transcription factors to acquire DNA. This is achieved by recruiting associated proteins and RNA polymerases. They modify the physical contact between cis-regulatory factor elements, transcription factors, and chromatin DNA to influence...
In order for DNA to fit within a cell's nucleus, it is wound up around histone proteins to form a structure called "chromatin." FromScience Daily Each macrophage contains a set of identity-forming instructions encoded in strands of DNA, which are wrapped around protein complexes called histones...
…exists in the form of chromatin, which is made up of DNA bound to histones (simple alkaline proteins) and other nonhistone proteins. Most of the DNA is complexed into repeating structures called nucleosomes, each of which contains eight molecules of histone. Active genes are found in parts...
Or we can say that chromatin contains proteins called histones. Chromatin is a packaging material for DNA. If not packed well, it can tangle around itself or get damaged during cell division. The size of cells is in micrometers and a DNA can be as long as 3 meters. In order to fit ...
characterization of unannotated proteins and regulatory mechanisms. In summary, our data confirm the importance of chromatin structural changes to regulate gene expression in the human malaria parasite. Precise knowledge of gene regulation pathways in the human malaria parasite will be essential for ...