This invention relates to an isolated nucleic acid fragment encoding a chromatin associated protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the chromatin associated protein, in sense or antisense orientation, wherein expression of the chimeric ...
但是,在人类基因组中编码的1,600多种转录因子中,只有一小部分被检测了。 这篇文章作为ENCODE项目的一部分,使用人类使用人类Hepg2细胞系中的208个染色质相关蛋白质(CAP)进行高通量测序,然后对得到的染色质免疫沉淀数据进行处理和分析。本文旨在尽可能完整的概述这种细胞类型的基因调控网络。 二、数据来源 ...
Electrophoretic analysis of nuclear matrix proteins and the potential clinical applications 1991, Journal of Chromatography B: Biomedical Sciences and Applications Show abstract Hepatoma-associated nonhistone chromosomal proteins 1984, BBA - Gene Structure and Expression ...
We applied our methodology to identify regulons that differentiate basal and luminal subtypes (Fig.5f). Using differential proteins associated with subtype-specific footprints, we build a protein–protein interaction network that is centered around known PAM50 genes (Fig.5f: green dots) (permutedpval...
The Set4 protein in the yeast Saccharomyces cerevisiae contains both a PHD finger and a SET domain, a common signature of chromatin-associated proteins, and shares sequence homology with the yeast protein Set3, the fly protein UpSET, and the human protein mixed-lineage leukemia 5 (MLL5). ...
The major focus of my current research is to study the post-translational modification of the proteins especially histone associated proteins and their potential roles in rendering cancer cells resistant to the therapeutic treatments. Interference with this alteration could result in the identification of...
Characterizing drug–target engagement is essential to understand how small molecules influence cellular functions. Here we present Chem-map for in situ mapping of small molecules that interact with DNA or chromatin-associated proteins, utilizing small-m
Procaryotic genomic DNA and associated proteins together form an irregularly shaped structure, designated as the nucleoid. In contrast to the range of different chromatin proteins identified in bacteria, almost all eucaryal genomes are compacted into nucleosomes, chromatin, and chromosomes by essentially...
Both Snf5Tt-FZZ and Saf5Tt-FZZ co-purified with 5 other proteins with no clear orthologs in other described SWI/SNF complexes. The first of these 5 proteins, Saf1 (SWI/SNF-associated factor 1, Table 1), is predicted to have a coiled coil and a transmembrane domain. Saf1 appears to ...
Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified unexpected synthetic lethal opportunities and enabled increasingly comprehensive structural and functional dissection. Here, we review recent progress in our understanding of oncogenic...