Chromatin modifying enzymes either add or remove post-translational modifications to histone proteins and in this way change the functional profile of the epigenome. Antagonizing enzymes, such as HATs and HDACs, often co-localize at chromatin regions and fine-tune gene expression. Chromatin modeling ...
Vogel, "Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins," Cell and Tissue Research, vol. 356, no. 3, pp. 507-526, 2014.Backofen R, Vogel T. Biological and bioinformatical approaches to study crosstalk of long- non-coding...
essential for sorting endosomal articles into multivesicular bodies (MVBs), as well as vital for the formation of these bodies. The MVBs pathway mediates distribution of transmembrane proteins into the lumen of the lysosome for degradation. CHMP1 interacts with VPS4B and localizes to early endosomes...
Epigenetic signals and chromatin-modifying proteins contribute to adipogenesis and, through regulation of the phenotypic maintenance of the mature adipocytes, to... MM Musri,R Gomis,M Párrizas - 《Organogenesis》 被引量: 70发表: 2010年 Chromatin and chromatin-modifying proteins in adipogenesis. Long...
Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic states of cells before and after reprogramming, the role of specific chromatin-...
SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Cell, 88 (1997), pp. 737-740 Google Scholar 32. Lorch Y, Zhang M, Kornberg RD Histone octamer transfer by a chromatin-remodeling complex Cell, 96 (1999), pp. 389-392 • of special interest Google...
To address how chromatin-modifying proteins influence reprogramming, we used shRNAs to target genes in DNA and histone methylation pathways, and have identified positive and negative modulators of iPSC generation. While inhibition of the core components of the polycomb repressive complex 1 and 2, ...
Gene inactivation studies of mammalian histone and DNA-modifying proteins have demonstrated a role for many such proteins in embryonic development. Post-im... P Mcdonel,I Costello,B Hendrich - 《International Journal of Biochemistry & Cell Biology》 被引量: 239发表: 2009年 ...
关键词: Chromatin Animals Humans Neoplasms Histone Deacetylases Acetylesterase Methyltransferases Phosphotransferases Chromosomal Proteins, Non-Histone Enzyme Inhibitors DOI: 10.1042/ 被引量: 26 年份: 2003 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Semantic Scholar (全网免费下载) 万方医学 ...
(a) the junction-resolving enzymes, (b) DNA repair proteins and transcription factors, (c) proteins involved in replication and (d) chromatin-associated ... V Brázda,RC Laister,EB Jagelská,... - 《Bmc Molecular Biology》 被引量: 150发表: 2011年 CREB, ATF, and AP-1 transcription fact...