Chromatin modifying enzymes either add or remove post-translational modifications to histone proteins and in this way change the functional profile of the epigenome. Antagonizing enzymes, such as HATs and HDACs, often co-localize at chromatin regions and fine-tune gene expression. Chromatin modeling ...
Vogel, "Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins," Cell and Tissue Research, vol. 356, no. 3, pp. 507-526, 2014.Backofen R, Vogel T. Biological and bioinformatical approaches to study crosstalk of long- non-coding...
Epigenetic signals and chromatin-modifying proteins contribute to adipogenesis and, through regulation of the phenotypic maintenance of the mature adipocytes, to... MM Musri,R Gomis,M Párrizas - 《Organogenesis》 被引量: 70发表: 2010年 Chromatin and chromatin-modifying proteins in adipogenesis. Long...
In mammalian cells, gene transcription is profoundly influenced by the epigenetic machinery, which includes histone/DNA modifying enzymes, non-coding regulatory RNAs, and chromatin remodeling proteins. Brahma-related gene 1 (BRG1) is the catalytic core of the mammalian SWI/SNF chromatin remodeling compl...
These novel connections are highly enriched for chromatin-modifying proteins, hinting at a universal role of chromatin regulation in cancer etiology. Although infrequently mutated as single genes, we show that chromatin modifiers are altered in a large fraction of cancer patients. In summary, we ...
While several proteins are known to regulate chromatin marks associated with the distinct epigenetic states of cells before and after reprogramming2,3, the role of specific chromatin modifying enzymes in reprogramming remains to be determined. To address how chromatin-modifying proteins influence ...
Association of receptor activity-modifying proteins (RAMP1-3) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables se... J Booe,CS Walker,J Barwell,... - 《Molecular Cell》 被引量: 42发表: 2015年 Activated Galphaq family members induce Rho GTPase activ...
Gene inactivation studies of mammalian histone and DNA-modifying proteins have demonstrated a role for many such proteins in embryonic development. Post-im... P Mcdonel,I Costello,B Hendrich - 《International Journal of Biochemistry & Cell Biology》 被引量: 239发表: 2009年 ...
Depletion or overexpression of some, but not all, chromatin modifying proteins affected HSV-1 transcription, but often in unexpected manners. Since 2010, it has become clear that both cellular and HSV-1 chromatins are highly dynamic in infected cells. These dynamics reconcile the weak interactions...
A consideration of the accruing evidence linking chromatin mod- ifications with SM gene cluster regulation led us to examine the hypothesis that additional chromatin-modifying proteins were impor- tant in SM gene cluster regulation. In particular, we examined a member of the complex associated ...