There are two characterized mechanisms for the function of modifications. The first is the disruption of contacts between nucleosomes in order to “unravel” chromatin and the second is the recruitment of nonhistone proteins. The second function is the most characterized to date. Thus, depending on...
Cooperative interactions between epigenetic modifications and their function in the regulation of chromosome architecture Epigenetic information is encoded by DNA methylation and by covalent modifications of histone tails. While defined epigenetic modification patterns have be... F Weissmann,F Lyko - 《Bioes...
Chromatin modifications and their function. Cell 128, 693–705 (2007). CAS PubMed Google Scholar Becker, J. S., Nicetto, D. & Zaret, K. S. H3K9me3-dependent heterochromatin: barrier to cell fate changes. Trends Genet. 32, 29–41 (2016). CAS PubMed Google Scholar Musselman, C....
Chromatin modifications and their function. Cell. 2007;128(4):693. Article CAS PubMed Google Scholar Wurtele H, Verreault A. Histone post-translational modifications and the response to DNA double-strand breaks. Curr Opin Cell Biol. 2006;18(2):137–44. Article CAS PubMed Google Scholar ...
Chromatin modifications and their function. Cell 128, 693–705 (2007). 35. Gyorgy, B., Toth, E., Tarcsa, E., Falus, A. & Buzas, E. I. Citrullination: a posttranslational modification in health and disease. Int. J. Biochem. Cell Biol. 38, 1662–1677 (2006). 36. Li, P. et ...
In this work, we explored the ALKBH1 genome-wide targets and its function in 6mA demethylation, chromatin modifications, and gene expression in plants. Our study uncovered that the ALKBH1-binding antagonizes PRC2 function to maintain a high H3K4me3/H3K27me3 ratio in its target genes to upregu...
T. Kouzarides Chromatin modifications and their function Cell, 128 (2007), pp. 693-705 View PDFView articleView in ScopusGoogle Scholar Lan et al., 2007 F. Lan, R.E. Collins, R. De Cegli, R. Alpatov, J.R. Horton, X. Shi, O. Gozani, X. Cheng, Y. Shi Recognition of unmethy...
what are the chromatin remodeling complexes and their activities what is the histone code hypothesis? - histone "tails" can be marked by different combinations of modifications - the hypothesis states that each marking conveys a specific meaning to the stretch of chromatin on which it occurs ...
In summary, BIND&MODIFY could precisely map histone modifications and protein interactions in challenging complex genome regions and phase the genome. Epigenomic status at single-molecule resolution Recent single-molecule and single-cell measurements of histone accessibility suggest that ATAC-seq of cell ...
Chromatin modifications and their function. Cell 128, 693–705 (2007). Article CAS Google Scholar Jasencakova, Z. & Groth, A. Restoring chromatin after replication: how new and old histone marks come together. Semin Cell Dev Biol 21, 231–237 (2010). Article CAS Google Scholar Orlando,...