chromatin-modifying elementexpression vectormatrix attachment regionUbiquitous chromatin open elementsinsulatorsstabilizing anti-repressor elementsMammalian cells are the preferred choice system for the production of complex molecules, such as recombinant therapeutic proteins. Although the technology for increasing ...
Drug analogues of metabolites that regulate chromatin-modifying enzyme reactions can also regulate cell fate by adjusting chromatin organization. In recent years, there have been many studies about how chromatin-modifying drug molecules or metabolites can interact with chromatin to regulate cell fate. In...
Chromatin-remodeling factors: machines that regulate? Curr Opin Cell Biol, 10 (1998), pp. 346-353 View PDFView articleView in ScopusGoogle Scholar 6. Kadonaga JT Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines Cell, 92 (1998), pp. 307-31...
To address how chromatin-modifying proteins influence reprogramming, we used short hairpin RNAs (shRNAs) to target genes in DNA and histone methylation pathways, and identified positive and negative modulators of iPSC generation. Whereas inhibition of the core components of the polycomb repressive ...
K. Archer, "Chromatin-modifying enzymes as therapeutic targets: part 2," Expert Opinion on Therapeutic Targets, vol. 12, no. 11, pp. 1457-1467, 2008.Chromatin-modifying enzymes as therapeutic targets--Part 2. Keppler BR,Archer TK. Expert Opinion on Therapeutic Patents . 2008...
Vogel, "Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs and chromatin-modifying proteins," Cell and Tissue Research, vol. 356, no. 3, pp. 507-526, 2014.Backofen R, Vogel T. Biological and bioinformatical approaches to study crosstalk of long- non-coding...
To address how chromatin-modifying proteins influence reprogramming, we used shRNAs to target genes in DNA and histone methylation pathways, and have identified positive and negative modulators of iPSC generation. While inhibition of the core components of the polycomb repressive complex 1 and 2, ...
NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components. Chromatin structure is important for the compaction of eukaryotic genomes, thus chromatin modifications play a fundamental role in regulating many cellular......
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. 来自 掌桥科研 喜欢 0 阅读量: 50 作者: Wood, Jason G.,Jones, Brian C.,Jiang, Nan,Chang, Chengyi,Hosier, Suzanne,Wickremesinghe, Priyan,Garcia, Meyrolin,Hartnett,...
We have attempted to reverse the silencing of this HSC genetic program by the sequential treatment of human cord blood CD34(+) cells with the chromatin-modifying agents, 5-aza-2'-deoxycytidine (5azaD) and trichostatin A (TSA). We determined that all CD34(+)CD90(+) cells treated with 5...