Crystal structures also provide the basis for comparative protein structure modeling which, by matching accuracy with intended use, may be used for virtual screening, defining antibody epitopes, protein engineering, rational mutagenesis, molecular replacement phasing, and fitting low resolution electron ...
2), enriched with CD56 antibody magnetic beads. It was shown that the NK cells concentration is a critical parameter during the optimization, as only at high concentration NK cells were able to promote tumor cell death before infiltration [65]. To improve the model relevance, Schnalzger et ...
et al. Enhanced antibody half-life improves in vivo activity. Nature Biotech. 28, 157–159 (2010). CAS Google Scholar Suzuki, T. et al. Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of ...
Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate pathogenesis. In RA, repeated monotherapy is frequently associated with inadequate efficacy, drug resistance, and severe side effects. Therefore, a shift has oc
Currently, innovative personalized approaches to immunotherapy are undergoing significant development. One such approach, adoptive T-cell therapy, which involves the infusion of engineered T cells into patients, has led to breakthroughs in the treatment of certain cancers [1,2]. This therapy entails ...
This leads to the formation of a membrane attack complex, resulting in the destruction of the target cell membrane and cell death. Fc‑mediated effector functions A collective term referring to antibody-dependent cellular cytotoxicity and complement- dependent cytotoxicity; these processes result in ...
and antibody secretion of B cells, and triggers a shift in macrophage polarization toward M2. MDSC proliferation and accumulation are facilitated by HLA-G. Additionally, HLA-G impairs the activation and antigen-presenting function of DCs and promotes tolerogenic DCs induction. To note, tumor cells...
On the other hand, endothelial cells' tight connections can be momentarily broken, allowing for temporary permeability to systemic drug molecules and a physical bypass of the BBB. To cross the BBB, RMT has undergone substantial research into the delivery of antibody–drug conjugates [79,80,81],...
A limited number of prospective studies with validation cohorts have been conducted to investigate pathogenesis and prediction of evolution to PASC. In a study involving 215 subjects and a 395 individuals validation cohort [72], an antibody signature (IgM and IgG3) together with a set of clinical...
In the management of B-cell lymphoma, the PD-1/PD-L1 blockade therapy has shown potential effects (Table 3). Recent studies have illuminated that a novel antibody (YM101) blocking TGF-β and PD-1/PD-L1 pathways and promoting the formation of "hot" immune-inflamed TME, shows better ...