Lee M. Recent advances in deep learning for protein–protein interaction analysis: a comprehensive review. Molecules. 2023;28(13):5169. Article CAS PubMed PubMed Central Google Scholar Myung Y, Pires DEV, Ascher DB. CSM-AB: graph-based antibody–antigen binding affinity prediction and docking...
Antibodies are proteins working in our immune system with high affinity and specificity for target antigens, making them excellent tools for both biotherapeutic and bioengineering applications. The prediction of antibody affinity changes upon mutations (ΔΔGbinding) is important for antibody engineering....
Machine learning (ML) is a key technology for accurate prediction of antibody–antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: the lack of a unified ML formalization of immunological antibody-specificity prediction prob...
et al. (2013) Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server. Bioinformatics, 29, 2285-2291.Olimpieri,P.P. et al. (2013) Prediction of site-specific interactions in antibody- antigen complexes: the proABC method and server. Bioinformatics,...
网络抗体交互作用;抗原抗体反应;抗体反应 网络释义
if the input is already encoded for the structural interaction betweenCDRs, surrounding residues, and the antigen, the model only needs to learn the semantic mapping rules, which might be more interpretable for antibody design. Zaixiang et al. found that implanting a structural adapter into a pr...
Antigen antibody interactions / Ruoslahti, E., 1976, Antigen-antibody interaction, antibody affinity and dissociation of immune complexes, in: Immunoadsorbents in Protein Purification ( E... FC Hay,OMR Westwood - Springer-Verlag, 被引量: 85发表: 1976年 Session 3: Signalisation and immune ...
Although the paratope prediction by fine-tuning the language model is a supervised task, the generation and comparison of neural embeddings of the paratope residues does not require further training. This provides great advantage because novel antibodies for novel antigens can be compared immediately ...
Consider first the simple 1–1 interaction of an antibody analyte that binds and unbinds to a structure containing a single antigen ligand. $${\sigma}_{\_}\mathop{\rightleftharpoons }\limits_{{k}_{-1}}^{{c}_{\mathrm{Ab}}{k}_{1}}{\sigma }_{\mathrm{Ab}},$$ (5) where σ...
Previous cross-docking attempts15, 16 on a dataset of diverse protein–protein complexes found the prediction of antibody–antigen interaction pairs to be especially difficult. In this paper, we present a cross-docking study to discriminate antibody–antigen binders from non-binders using a dataset ...