Biophysics Computational antibody structure prediction and antibody-antigen docking THE JOHNS HOPKINS UNIVERSITY Jeffrey J. Gray SircarAroopAntibodies are proteins that are the recognition elements of the immune system and increasingly used as drugs. Antibodies bind tightly and specifically to antigens to ...
Antibodies have the capacity to bind a diverse set of antigens, and they have become critical therapeutics and diagnostic molecules. The binding of antibodies is facilitated by a set of six hypervariable loops that are diversified through genetic recombination and mutation. Even with recent advances,...
The proposed method outperforms other antigen-binding interface prediction software, namely Paratome, Antibody i-Patch and Parapred, on a novel dataset of experimentally-solved antibody—antigen complex structures. 展开 关键词: Antibody interface Paratope 3D Zernike descriptors SVM AAindex ...
While computational methods can guide the search of biologically relevant antibodies, most de novo approaches require target structures or antibody-epitope complex structures to be known5,6,7. Machine learning (ML) approaches can be used to effectively represent biological data and rapidly explore their...
Material to run the HADDOCK antibody-antigen modelling protocol antibody haddock utrecht-university Updated Jan 2, 2024 Python kevinmicha / ANTIPASTI Star 22 Code Issues Pull requests ANTIPASTI (ANTIbody Predictor of Affinity from STructural Information) is a Deep Learning model that predicts...
strpred.ymlSample only thestructureofoneCDR (structure prediction). Antibody-Antigen Complex Below is the usage ofdesign_pdb.py. It samples CDRs for antibody-antigen complexes. The full list of options can be found indiffab/tools/runner/design_for_pdb.py. ...
An effective docking algorithm for antibody-protein antigen complex prediction is an important first step toward design of biologics and vaccines. We have ... B Ryan,DR Hall,C Gwo-Yu,... - 《Bioinformatics》 被引量: 100发表: 2012年 Predicting antibody complementarity determining region structures...
The immunological detection method, which is based on the specific binding of antigen and antibody, has the advantages of simple operation, short detection time, and is very suitable for on-site detection. The MOF-based virus immunological detection can be divided into two categories: antigen-...
Structure-based workflows for assessing and improving the developability, stability, affinity, and ‘humanness’ of antibody therapeutics with BioLuminate
Three-dimensional structure of an antibody-antigen complex Proc. Natl. Acad. Sci. USA, 84 (1987), pp. 8075-8079 Google Scholar 40 H. Shirai, A. Kidera, H. Nakamura Structural classification of CDR-H3 in antibodies FEBS Lett., 399 (1996), pp. 1-8 Google Scholar 41 M. Shoham Crystal...